Effect of Bacopa Monnieri on Working Memory and Cognitive Processing in Student
- Conditions
- Healthy
- Interventions
- Dietary Supplement: Bacopa Monnieri 600 mg/dayDietary Supplement: PlaceboDietary Supplement: Bacopa Monnieri 300 mg/day
- Registration Number
- NCT02931747
- Lead Sponsor
- Khon Kaen University
- Brief Summary
The purpose of this study is to determine the effect of Bacopa Monnieri on working memory and cognitive processing in student.
- Detailed Description
Learning and working memory are two of the key role for studying and work successful for student particular the high school student who study hard and preparing themselves for the graduate study. The consumption of brain booster product or functional food for improving memory has gained much attention. It has been reported that Bacopa Monnieri could improve learning and working memory in elderly subject by improving the N100 and P300 event related potential. Therefore, Bacopa Monnieri might be the potential product for improving the learning and working memory in student particular high school student.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 75
- Healthy student subject aged between 15-18 years old who studying in the school within Khon Kaen province.
- Body mass index is between 18.5-24.9
- Subjects who are diagnosed with one of the following: cardiovascular diseases, respiratory disease, neuropsychological diseases, head injury, diabetes mellitus, liver disease, cancer, autoimmune disease and hematological disorder are excluded.
- Subjects who take any medicine or nutraceuticals or hormone that effect on central nervous system are excluded.
- Alcohol addict or smoking addiction (more than 10 pieces/day)
- Athlete or subjects who have a regular exercise more than 3 times/week
- Subjects who don't follow the instruction during the trial
- Subjects who are participating the other project.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Bacopa Monnieri 600 mg/day Bacopa Monnieri 600 mg/day Subjects are received the pill of Bacopa Monnieri at the dose of 600 mg/day once daily for 16 weeks Placebo Placebo Subjects are received the pill of placebo which has same color, shape and smell like the Bacopa Monnieri once daily for 16 weeks. Bacopa Monnieri 300 mg/day Bacopa Monnieri 300 mg/day Subjects are received the pill of Bacopa Monnieri at the dose of 300 mg/day once daily for 16 weeks
- Primary Outcome Measures
Name Time Method Attention using the latency of N100 wave 4 months The latency of N100 wave was measured and expressed as millisecond.
Attention using the amplitude of N100 wave 4 months The amplitude of N100 wave was measured and expressed as micro-volt.
Cognitive processing using the amplitude of P300 wave 4 months The amplitude of P300 wave was measured and expressed as micro-volt.
Cognitive processing using the latency of P300 wave 4 months The latency of P300 wave was measured and expressed as millisecond.
- Secondary Outcome Measures
Name Time Method Glutamic acid decarboxylase (GAD) activity in serum 4 months Malondialdehyde level in serum 4 months Assessment of mood scale using Bond-Lader visual analogue scales 4 months Gamma-aminobutyric acid (GABA)-transaminase in serum 4 months Activity of glutathione peroxidase in serum 4 month Consumption safety of Bacopa Monnieri using hematological values . 4 month The hematological values including red blood cell, white blood cell, hematocrit and platelet were determined and the data was expressed as number of subject presented with abnormal hematological value.
Consumption safety of Bacopa Monnieri using blood chemistry 4 month The blood chemistry values including renal function test, liver function test, lipid profile, electrolytes and glucose were determined and the data was expressed as number of subject presented with abnormal blood chemistry value.
Consumption safety of Bacopa Monnieri using blood pressure measurement 4 month Assessment of psychiatric symptoms using the symptom check list 90 (SCL-90) 4 months Activity of superoxide dismutase in serum 4 month Consumption safety of Bacopa Monnieri using electrocardiogram (EKG) 4 month Accuracy of working memory using computerized battery test 4 months The accuracy of working memory was determined and expressed as percentage.
Activity of catalase in serum 4 month Speed of working memory using computerized battery test 4 months The speed of working memory was determined and expressed as millisecond.
Acetylcholinesterase activity in serum 4 months Monoamine oxidase activity in serum 4 months
Trial Locations
- Locations (1)
Jitanaporn Wattanathorn
🇹ðŸ‡Khon Kaen, Thailand