The Effect of Aronia Melanocarpa Extract on Cognitive Function

Not Applicable

Completed

• Conditions: Cognitive Function
• Interventions: Dietary Supplement: Placebo; Dietary Supplement: Aronia

• Registration Number: NCT03793777
• Lead Sponsor: Maastricht University Medical Center

Brief Summary

There is a great interest in improving cognitive performance, including memory and attention. Improved attention is desirable for a large group of people because it is linked to improved performance . Students and professionals can benefit from improved attention and thus performance in academic and other work environments. In addition, cognitive functioning also plays an important role in sports. Various cognitive skills, including attention, reaction time and motor function, have shown that they can influence sport performance. A completely natural supplement with aronia melanocarpa extract could be a promising way to naturally improve cognitive performance.

Detailed Description

There is a great interest in improving cognitive performance, including memory and attention. Improved attention is desirable for a large group of people because it is linked to improved performance. Students and professionals can benefit from improved attention and thus performance in academic and other work environments. In addition, cognitive functioning also plays an important role in sports. Various cognitive skills, including attention, reaction time and motor function, have shown that they can influence sport performance. A completely natural supplement with aronia melanocarpa extract could be a promising way to naturally improve cognitive performance. The product in this study is aronia melanocarpa which contains polyphenols. A limited number of clinical studies have already been carried out to see the effect of similar products on cognitive functioning. However, these studies have often been done in older study populations or over a longer period of time. In this study, in healthy adolescents (ages between the 18-35 and with a BMI between 18.5 and 30), the investigators want to test the short term (7 days) effect of aronia melanocarpa extract on cognitive functioning. The investigators will also test the effect of supplementation on the particpant's mood, vascular function, blood biomarkers, retinal vasculature, and subjective cognition.

Study Timeline

• Study First Submitted: 2018-12-19
• Study First Submitted QC: 2019-01-02
• Study First Posted: 2019-01-04
• Status Verified: 2020-09
• Study Start: 2020-10-09
• Primary Completion: 2021-04-29
• Study Completion: 2021-04-29
• Last Update Submitted: 2021-09-03
• Last Update Posted: 2021-09-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Healthy young adults: ages between 18 and 35
• BM between 18.5-30 kg/m2

Exclusion Criteria

• Current use of (antioxidant) dietary supplements and not willing to quit for the duration of the study duration
• Pre-existing or history of neurological illness
• High blood pressure (>140 systolic and/or >90 diastolic mmHg)
• Use of medication that might have influence on endpoints (e.g. antidepressant)
• Known pregnancy or lactation
• Food allergy to the study product
• Administration of investigational drugs or participation in any scientific intervention study which may interfere with this study, to be decided by the principle investigator, in the 180 days prior to the study
• Abuse of products (> 20 alcoholic consumptions per week and drug usage)
• Participation in a scientific intervention study which may interfere with this study in the 180 days prior to this study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
placebo	Placebo	microcrystalline cellulose supplementation
Aronia	Aronia	aronia melanocarpa supplementation

Primary Outcome Measures

Name	Time	Method
Cognitive function	After 7 days of supplementation	CANTAB

Secondary Outcome Measures

Name	Time	Method
Mood	After 7 days of supplementation	VAMS
Vascular function	After 7 days of supplementation	SBP \& DBP, PWA \& PWV
Biomarkers in blood and saliva	After 7 days of supplementation	BDNF \& cortisol
Subjective cognition	After 7 days of supplementation	Cognitive Failures Questionnaire
Microvasculature	After 7 days of supplementation	Fundus photography

Trial Locations

Locations (1)

Maastricht University; 🇳🇱 Maastricht, Limburg, Netherlands