NCT04434118撤回不适用
Anti-rheumatic Drug Use and Risk of COVID-19 Infection in Rheumatoid Arthritis Patients: A Retrospective, Case-control Study
Sadat City University1 个研究点 分布在 1 个国家开始时间: 2020年3月20日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 试验地点
- 1
- 主要终点
- The risk of COVID-19 infection among RA patients
研究概览
简要总结
Rheumatoid arthritis (RA) patients have an underlying immune deficiency and typically treated with immunosuppressive drugs, which may increase the risk of COVID-19 infection. Hydroxychloroquine (HCQ) has been found to possess antiviral activity against COVID-19. Thus, the aim of this study to investigate the ability of HCQ to reduce the risk of COVID-19 among RA patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Data of all definite cases of RA were collected and reviewed from complete medical records of patients by a team that included 2 trained physicians using a pretested data collection form.
排除标准
- •The exclusion criteria were included incomplete medical records or those with difficulty to communicate with the patients.
- •Patients with acute lethal organ injury (e.g., acute myocardial infarction, acute coronary syndrome, acute pulmonary embolism, or acute stroke)
- •Patients with decompensated or end stage chronic organ dysfunction (e.g., decompensated cirrhosis, decompensated chronic renal insufficiency, or severe congestive heart failure), diabetes mellitus, data of pregnant females, acquired immune deficiency syndrome (aids), and leukemia or other malignancies.
研究组 & 干预措施
Rheumatoid Arthritis with COVID-19
干预措施: Traditional antirheumatic drugs (Drug)
Rheumatoid Arthritis without COVID-19
干预措施: Traditional antirheumatic drugs (Drug)
结局指标
主要结局
The risk of COVID-19 infection among RA patients
时间窗: 12 week
Realtion between hydroxychloroquine use and COVID-19 infection
次要结局
- The incidence of hospitalization for Covid-19 patients.(12 week)
研究者
Mahmoud Samy Abdallah
Lecturer of Clinical Pharmacy, PhD.
Sadat City University
研究点 (1)
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