Absorption, Metabolism and Excretion of Oat Phenolic Acids in Healthy Men.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Reading
- Enrollment
- 7
- Locations
- 1
- Primary Endpoint
- Change from baseline in phenolic acid metabolite excretion
Study Overview
Brief Summary
A diet rich in whole grain is inversely associated with cardiovascular disease risk and this benefit could be partly attributed to the phenolic acid content of whole grains. The exact absorption, metabolism and excretion of whole grain phenolic acids, however, is not fully understood. In a small human intervention trial, the investigators will investigate to what extent phenolic acids from whole grain oats are absorbed, excreted in urine and how they are metabolised.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 25 Years to 65 Years (Adult, Older Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •25 to 65 years old
Exclusion Criteria
- •Allergies to oats
- •Parallel participation in another research project
- •Having flu vaccination or antibiotics within 3 months of trial start
- •Taking food supplements within 3 months of trial start
- •Past or existing medical history of vascular disease, diabetes, hepatic, renal, gastrointestinal, haematological, neurological, thyroidal disease or cancer
Arms & Interventions
Oat bran
66g oat bran made up in 350ml skimmed milk
Intervention: Oat bran (Dietary Supplement)
Control
Refined grain product and 350ml skimmed milk
Intervention: refined grain (Dietary Supplement)
Outcomes
Primary Outcomes
Change from baseline in phenolic acid metabolite excretion
Time Frame: Baseline and 48 hours
Secondary Outcomes
No secondary outcomes reported
Investigators
Jeremy Paul Edward Spencer
Professor
University of Reading