Effects of remote ischemic preconditioning in cardiac surgery on incidence and severity of acute kidney injury

Not Applicable

• Conditions: OPS-2013: 5-35, 5-361 (bypass surgery, cardiac valve and septum surgery); N17; Acute renal failure

• Registration Number: DRKS00005333
• Lead Sponsor: niversitätsklinikum MünsterKlinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-11-05
• Study Completion: 2014-10-23
• Results First Posted: 2015-06-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 240

Inclusion Criteria

1. Cardiac Surgery with the use of cardiopulmonary bypass
2. Clevelandscore of 6 or more
3. Informed consent

Exclusion Criteria

1. pre-existing AKI
2. kidney transplantation
3. chronic kidney disease with a GFR < 30 ml/min
4. myocardial infarction within the past 7 days
5. peripheral vascular disease affecting the upper limbs
6. hepatorenal syndrome
7. pregnancy
8. drug therapy with sulfonamide and nicorandil

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of acute renal failure

Secondary Outcome Measures

Name	Time	Method
- Severity of acute kidney injury (AKIN criteria)<br>- Duration of renal replacement therapy<br>- Recovery of renal function (Incidence of RRT (renal replacement therapies) on hospital discharge and 3 months after surgery)<br>- Length of ICU stay<br>- Length of hospitalization<br>- Laboratory parameter (creatinine on hospital discharge)