The Metabolic Effects of Breaks in Sedentary Time
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- Change in Insulin Net Incremental Area-Under-The-Curve (iAUC)
研究概览
简要总结
The purpose of this study is to determine whether acute bouts of sedentary behaviour (with or without breaks and/or structured physical activity) result in measurable changes in metabolic health in children and youth.
详细描述
North American children spend the majority of their waking hours engaging in sedentary behavior (e.g. sitting). Research in adults and animal models suggests that even short bouts of uninterrupted siting may result in acute changes increases in cardiometabolic risk, although to date no studies have investigated this relationship in children and youth. The purpose of this study is to assess the feasibility of a protocol which will expose participants aged 10-14 years to a full day of uninterrupted sitting, and to determine the impact of this protocol on markers of cardiometabolic risk (insulin, glucose, triglyceride, HDL-C and LDL-C) as well as subsequent food intake and physical activity. The impact of uninterrupted sitting will be compared to the impact of interrupted sitting, with and without the inclusion of moderate physical activity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 10 Years 至 14 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 10-14
- •Normal weight or obese
排除标准
- •Overweight
- •Overt diabetes or heart disease (or taking medications to treat this conditions)
- •Being unambulatory or otherwise unable to perform the study protocol
研究组 & 干预措施
Sedentary
In this condition, participants will engage in 8 hours of uninterrupted sedentary behaviour.
干预措施: Sedentary (Other)
Sedentary With Breaks
In this condition participants will engage in 8 hours of sitting, although the sitting will be interrupted every 20 minutes. During these interruptions participants will spend 2 minutes walking at an intensity equivalent to 30% of VO2peak.
干预措施: Sedentary With Breaks (Other)
Sedentary With Breaks and Physical Activity
In this condition participants will engage in 8 hours of sitting, although the sitting will be interrupted every 20 minutes. During these interruptions participants will spend 2 minutes walking at an intensity equivalent to 30% of VO2peak. Participants will also engage in 20 minutes of structured physical activity at an intensity of 60% of VO2peak in both the morning and afternoon.
干预措施: Sedentary With Breaks and Physical Activity (Other)
结局指标
主要结局
Change in Insulin Net Incremental Area-Under-The-Curve (iAUC)
时间窗: Baseline, 1.5, 3, 4.5, 6, and 7.5 hours
Insulin levels will be assessed multiple times throughout the day, and the resulting values will be used to calculate AUC.
次要结局
- Change in Triglyceride Net Incremental Area-Under-The-Curve (iAUC)(Baseline, 1.5, 3, 4.5, 6, and 7.5 hours)
- Change in Glucose Net Incremental Area-Under-The-Curve (iAUC)(Baseline, 1.5, 3, 4.5, 6, and 7.5 hours)
- Change in HDL-Cholesterol (HDL-C) Net Incremental Area-Under-The-Curve (iAUC)(Baseline, 1.5, 3, 4.5, 6, and 7.5 hours)
- Change in LDL-Cholesterol (LDL-C) Net Incremental Area-Under-The-Curve (iAUC)(Baseline, 1.5, 3, 4.5, 6, and 7.5 hours)
研究者
Mark Tremblay
Dr Mark Tremblay, Director, Healthy Active Living and Obesity Research Group
Children's Hospital of Eastern Ontario