The Metabolic Effects of Breaks in Sedentary Time

Not Applicable

Completed

• Conditions: Lipids; Feasibility; Glucose; Eating; Insulin

• Registration Number: NCT01398059
• Lead Sponsor: Children's Hospital of Eastern Ontario

Brief Summary

The purpose of this study is to determine whether acute bouts of sedentary behaviour (with or without breaks and/or structured physical activity) result in measurable changes in metabolic health in children and youth.

Detailed Description

North American children spend the majority of their waking hours engaging in sedentary behavior (e.g. sitting). Research in adults and animal models suggests that even short bouts of uninterrupted siting may result in acute changes increases in cardiometabolic risk, although to date no studies have investigated this relationship in children and youth. The purpose of this study is to assess the feasibility of a protocol which will expose participants aged 10-14 years to a full day of uninterrupted sitting, and to determine the impact of this protocol on markers of cardiometabolic risk (insulin, glucose, triglyceride, HDL-C and LDL-C) as well as subsequent food intake and physical activity. The impact of uninterrupted sitting will be compared to the impact of interrupted sitting, with and without the inclusion of moderate physical activity.

Study Timeline

• Study Start: 2011-07
• Study First Submitted: 2011-07-18
• Study First Submitted QC: 2011-07-19
• Study First Posted: 2011-07-20
• Primary Completion: 2012-08
• Study Completion: 2012-08
• Results First Submitted: 2018-04-23
• Status Verified: 2019-05
• Results First Submitted QC: 2019-05-22
• Last Update Submitted: 2019-05-22
• Results First Posted: 2019-07-24
• Last Update Posted: 2019-07-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 19

Inclusion Criteria

• Age 10-14
• Normal weight or obese

Exclusion Criteria

• Overweight
• Overt diabetes or heart disease (or taking medications to treat this conditions)
• Being unambulatory or otherwise unable to perform the study protocol

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Change in Insulin Net Incremental Area-Under-The-Curve (iAUC)	Baseline, 1.5, 3, 4.5, 6, and 7.5 hours	Insulin levels will be assessed multiple times throughout the day, and the resulting values will be used to calculate AUC.

Secondary Outcome Measures

Name	Time	Method
Change in Triglyceride Net Incremental Area-Under-The-Curve (iAUC)	Baseline, 1.5, 3, 4.5, 6, and 7.5 hours	Blood draws will be taken several times throughout the day, and the resulting values will be used to calculate AUC.
Change in Glucose Net Incremental Area-Under-The-Curve (iAUC)	Baseline, 1.5, 3, 4.5, 6, and 7.5 hours	Blood draws will occur throughout the day, and the resulting values will be used to calculate AUC.
Change in HDL-Cholesterol (HDL-C) Net Incremental Area-Under-The-Curve (iAUC)	Baseline, 1.5, 3, 4.5, 6, and 7.5 hours	Blood draws will occur throughout the day, and the resulting values will be used to calculate AUC.
Change in LDL-Cholesterol (LDL-C) Net Incremental Area-Under-The-Curve (iAUC)	Baseline, 1.5, 3, 4.5, 6, and 7.5 hours	Blood draws will occur throughout the day, and the resulting values will be used to calculate AUC.

Trial Locations

Locations (1)

Behavioural Metabolic Research Unit, University of Ottawa; 🇨🇦 Ottawa, Ontario, Canada