Changes in Elastic Properties of Descending Thoracic Aorta After Ascending Aorta Replacement

Completed

• Conditions: Aortic Surgery

• Registration Number: NCT03817008
• Lead Sponsor: Centre Hospitalier La Chartreuse

Brief Summary

The aim of our study was to evaluate the impact of aortic root replacement by a graft on the elastic properties of the descending thoracic aorta using cardiac Magnetic Resonance Imaging (MRI) and automatic post-processing.

Nineteen patients were operated on an aortic root aneurysm and a cardiac MRI allowing aortic compliance measurement was performed before and after surgery. Images were acquired with a 1.5 T MRI with only one additional sequence to a conventional aortic MRI protocol.

Detailed Description

Observational and retrospective trial on medical data only. The patients are operated of planned aortic root aneurysm without additional intervention.

The pre and postoperative cardiac MRI are planned in standard of care.

Study Timeline

• Study Start: 2014-09-01
• Status Verified: 2019-01
• Primary Completion: 2019-01-17
• Study Completion: 2019-01-17
• Study First Submitted: 2019-01-17
• Study First Submitted QC: 2019-01-24
• Last Update Submitted: 2019-01-24
• Study First Posted: 2019-01-25
• Last Update Posted: 2019-01-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 19

Inclusion Criteria

• > 18 years
• Elective patient
• Ascending aorta replacement with graft

Exclusion Criteria

• Prior cardiac surgery
• Contraindication to performing cardiac MRI

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Aortic compliance of descending aorta (mm2/mmHg)	post-operative cardiac MRI performing between 12 and 24 months	Aortic elastic properties of the descending aorta before and after aortic root replacement using cardiac MRI.; Aortic compliance is a local measurement of elastic properties which is obtained with cardiac MRI images by computer processing.

Secondary Outcome Measures

Name	Time	Method
Aortic compliance of ascending aorta (mm2/mmHg)	post-operative cardiac MRI performing between 12 and 24 months	Aortic elastic properties of the ascending aorta before and after aortic root replacement using cardiac MRI.; Aortic compliance is a local measurement of elastic properties which is obtained with cardiac MRI images by computer processing.