Embryo Transfer in Natural vs Substituted Cycle and the Scheduling Pattern of IVF
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,207
- 试验地点
- 1
- 主要终点
- Evaluate the clinical pregnancy rate of embryo transfer in natural vs substituted cycles
研究概览
简要总结
In frozen embryo transfer substituted cycles, patients are treated with progesterone and estrogen in an attempt to mimic the natural cycle and a transfer is planned whenever the endometrium is ready. In contrast, in frozen embryo transfer natural cycle patients are not taking any hormones, only triggered with hCG (human chorionic gonadotropin) when a dominant follicle is ready or they wait for the disappearance of the dominant follicle to plan the transfer date. Some doctors and centres shift towards using the substituted protocol in an attempt to make scheduling easier with less frequent ultrasounds.
This study will aim to compare clinical and biochemical pregnancy rates in patients who underwent frozen embryo transfers in natural cycles vs substituted cycles at the centre.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 40 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age < 40 years old
- •Women having undergone either a frozen embryo transfer in natural cycle or substituted cycle
- •IVF and FET cycles done at Clinique OVO
排除标准
- •egg or embryo recipient
- •History of recurrent miscarriages, defined as ≥ 3 consecutive losses
- •Patients that needed Viagra, Plasma-Rich Platelet (PRP) or other modalities to improve their endometrial thickness
- •Uterine abnormalities
- •Abnormal hormonal profiles
- •FET Stimulated cycles
- •History of recurrent implantation failure defined as failed ≥ 2 euploid embryos transfer or ≥ 3 blastocysts
结局指标
主要结局
Evaluate the clinical pregnancy rate of embryo transfer in natural vs substituted cycles
时间窗: 6 to 8 weeks after Frozen Embryo Transfer
clinical pregnancy is the presence of fetal heartbeat at the viability ultrasound
次要结局
未报告次要终点