Transfer of Frozen Embryos in Natural Cycle: Evaluation of Impact of Spontaneous Versus HCG-triggered Ovulation on Pregnancy Rate
Not Applicable
Completed
- Conditions
- in Vitro Fertilization
- Registration Number
- NCT03428165
- Lead Sponsor
- Centre Hospitalier Universitaire de Nīmes
- Brief Summary
The purpose of the study is to evaluated whether there is a difference in pregnancy rate when transferring frozen embryos between patietns having spontaneously ovulated versus those triggered to voulate with HCG.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 103
Inclusion Criteria
- The patient must have given their free and informed consent and signed the consent form
- The patient must be a member or beneficiary of a health insurance plan
- The patient is aged between 18 and 40
- Patient has regular cycles and classified as 'easy' for transfer of a frozen embryo at blastocyste stage (vitrification day 5)
Exclusion Criteria
- The subject is participating in an interventional study, or is in a period of exclusion determined by a previous study
- The subject refuses to sign the consent
- It is impossible to give the subject informed information
- The patient is under safeguard of justice or state guardianship
- Patient using donated oocytes
- Necessity of pre-implantation diagnosis
- Patients with stage 3 or 4 endometriosis or adenomyosis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Pregnancy rate after transfer of frozen embryos at day 14 between groups Day 14 Yes/no; Blood ßHCG \> 100UI/L
- Secondary Outcome Measures
Name Time Method Pregnancy rate at week 12 Week 12 Yes/no; ultrasound
Miscarriage rate within first 12 weeks Week 12 Yes/no; ultrasound
Cancellation of transfer due to premature ovulation (progesterone >3ng/ml and/or Luteinizing hormone > 3-fold base level) Day 0 Yes/no
Number of visits for endometrial preparation until attaining LH peak Day 0 Number of visits
Pregnancy term At delivery, maximum week 42 Weeks
Birth weight At delivery, maximum week 42 Kg
Live birth At delivery, maximum week 42 Yes/no
Trial Locations
- Locations (2)
CHU Arnaud de Villeneuve
🇫🇷Montpellier, France
CHU Nimes
🇫🇷Nîmes, France
CHU Arnaud de Villeneuve🇫🇷Montpellier, France