Evaluation of limb muscle and diaphragm atrophy in critically ill patients
Not Applicable
Recruiting
- Conditions
- Patients admitted in the IC
- Registration Number
- JPRN-UMIN000031316
- Lead Sponsor
- Tokushima university hospital
- Brief Summary
Biceps brachii thickness and cross-sectional area decreased by 6.5, 11.0, and 13.2% (p < 0.01), and by 8.3, 11.1 and 16.9% on day 3, 5, and 7 (p < 0.01), respectively (Fig. 1). Rectus femoris thickness and cross-sectional area decreased by 7.4, 11.1, and 18.8%, and by 8.7, 13.7, and 20.7% on days 3, 5, and 7 (p < 0.01), respectively.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 28
Inclusion Criteria
Not provided
Exclusion Criteria
We excluded patients who fell under one or more of the following categories: exhibiting trauma to or amputation of limbs; diagnosed with primary neuromuscular disease.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The change of thickness and cross-sectional area about limb muscle and diaphragm on days 1, 2, 3, 5, 7,and 10 with serial ultrasonographic measurements after ICU admission
- Secondary Outcome Measures
Name Time Method The change of following several parameters on days 1, 2, 3, 5, 7, and 10 after ICU admission Muscle strength by MRC score Muscle strength by hand dynamometer Thickening fraction of diaphragm by ultrasonography The change of intercostal muscle thickness by ultrasonography Texture analysis of limb and diaphragm muscle by ultrasonography Muscle mass by bioelectrical impedance analysis FSS-ICU and ICU mobility Scale Titin in urine Biomarker in urine and blood