Possible Role of Coenzyme Q10 in Prevention of Contrast Induced Nephropathy in Patients With Acute Coronary Syndrome Undergoing Coronary Angiography With or Without Intervention.
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 入组人数
- 250
- 试验地点
- 2
- 主要终点
- Percentage of the Creatinine rise in 1st 48-72 hours in ccu
研究概览
简要总结
In this study the investigators aim to study the effect of supplementation of CoQ10 in decreasing the incidence of contrast induced acute kidney injury in patients with acute coronary syndrome undergoing coronary angiography.
详细描述
Patients who fulfilled the inclusion criteria and agreed to participate in the study will be randomly divided into 2 groups using their computer generated random numbers that group a will receive the coenzyme Q10 in addition to the standard preventive measures and group b will receive only the standard preventive measures without the coenzyme Q10.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who are 18 years or older.
- •ST-elevation myocardial infarction (STEMI).
- •Non ST-elevation myocardial infarction( NSTEMI).
- •Unstable Angina (UA)
排除标准
- •Renal transplant patients.
- •Preoperative bleeding .
- •Intraoperative bleeding or hypotension.
- •Patients taking any nephrotoxic medications
研究组 & 干预措施
Coenzyme Q10 100 Milligrams Oral Capsule
Coenzyme Group received coenzyme Q10 in addition to the the standard preventive measures
干预措施: Coenzyme Q10 100 Milligrams Oral Capsule (Drug)
Placebo group
Placebo Group received only the standard preventive measures
干预措施: Placebo (Drug)
结局指标
主要结局
Percentage of the Creatinine rise in 1st 48-72 hours in ccu
时间窗: 48-72 hours
a rise in serum creatinine of at least 0.5 mg/dL or a 25% increase from baseline within 48 to 72 hours after contrast exposure
次要结局
未报告次要终点