Effects of Coenzyme Q10 (CoQ10) on Subjects With Charcot-Marie-Tooth Disease (CMT):A Double Blind, Randomized, Controlled Trial With an Open Label Follow-up Study
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- Changes in weakness, fatigue and pain in persons with Charcot-Marie-Tooth disease after supplementation with 600 mgs a day of Coenzyme Q10.
研究概览
简要总结
The object of this research is to test the effectiveness of Coenzyme Q10 (CoQ10) on symptoms of weakness, fatigue, and pain in persons with Charcot-Marie-Tooth disease (CMT).In this study we also intend to examine the impact of daily supplementation on overall quality of life.We are also interested in identifying any differences in serum ratios of CoQ10 in the oxidized and reduced forms.
详细描述
CoQ10 is an integral part of the electron transport chain in the mitochondria, or the energy production centers of cells. Within recent years, there has been expanding interest in the potential benefits of CoQ10 supplementation on a variety of neuromuscular diseases, some of which involve mitochondrial dysfunction, such as CMT. Daily supplementation may have cytoprotective and neuroprotective properties, which may improve symptoms of weakness, fatigue, and pain, as well as increase quality of life (QOL) among persons with CMT.
With regards to within group comparisons we hypothesize that daily supplementation of CoQ10 taken as a 300 milligram wafer twice a day for 3 months will produce a statistically significant reduction in weakness, fatigue, and pain, along with a significant improvement in QOL as indicated from scores in both standardized physiological and scale measures.
The addition of serum level analysis will help to contextualize clinical results. We hypothesize the ratios of the oxidized and reduced forms of CoQ10 will be modified upon supplementation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects must have a diagnosis of CMT, confirmed by review of medical records by the study physician
- •Subjects can be of either gender
- •Subjects must be between the ages of 18 and 75
- •Subjects must be able to complete all assessments at the designated time intervals
- •Subjects must review and sign the informed consent statement according to Conemaugh Memorial Medical Center's (CMMC) Institutional Review Board (IRB) guidelines
- •Subjects must receive approval from their primary care physician (PCP) to enroll in the study
- •Regarding weakness, fatigue, and pain, subjects must experience at least two of the three symptoms on most days over the past month
- •Regarding weakness, fatigue, and pain, subjects must report experiencing maximum levels of >/= 3.0 centimeters (cm) on the 10 cm visual analog scale (VAS) for any two of the three symptoms over the past month
- •Female subjects must be willing to practice stable birth control during involvement in the study
- •Subjects must agree to be randomized
排除标准
- •Subjects having another general medical condition, which might confound the assessment of weakness, fatigue, and pain due to CMT
- •Subjects taking warfarin or Coumadin
- •Subjects who are pregnant, verified by a urine pregnancy test*
- •Subjects having a cognitive impairment scoring < 20 on the Mini-Mental State Exam
- •Subjects who are currently using CoQ10 supplementation or have used it in the past 6 months
- •Subjects with a history of chronic liver disease or other condition causing malabsorption
- •Drug intake that could modify lipid absorption (such as statins)
- •Subjects who consume >3 alcoholic drinks per day on more than one occasion per month
- •Subjects with abnormal liver function tests as defined through a Hepatic -Function Panel or a Liver Function Panel
- •Women of childbearing age who have had at least one menstrual cycle within the past 12 months and who have not undergone a sterilization procedure will undergo a urine pregnancy test at visits 1-10 regardless of group assignment in order to maintain the single blind. The urine samples will be processed at CMMC's lab
研究组 & 干预措施
1
300 mg CoQ10 chewable wafer twice a day
干预措施: Coenzyme Q10 (Dietary Supplement)
2
Chewable placebo wafer twice a day for 24 weeks with crossover to 300mg CoQ10 twice a day for weeks 24-48.
干预措施: Coenzyme Q10 (Dietary Supplement)
结局指标
主要结局
Changes in weakness, fatigue and pain in persons with Charcot-Marie-Tooth disease after supplementation with 600 mgs a day of Coenzyme Q10.
时间窗: 60 weeks
次要结局
- Improvements in quality of life in subjects with CMT before and after CoQ10 supplementation.(60 weeks)
- Measure blood serum levels of the oxidized and reduced forms of CoQ10.(60 weeks)
- Measure liver function tests(visits 1, 6, 12)