Does Caffeine Affect the Sensitivity of Adenosine Perfusion Scans?

Not Applicable

Completed

• Conditions: Coronary Artery Disease
• Interventions: Procedure: Cardiac SPECT imaging Rest and Stress; Drug: Caffeine

• Registration Number: NCT00205166
• Lead Sponsor: University of Wisconsin, Madison

Brief Summary

We are studying the affect of caffeine on the sensitivity of detecting coronary artery disease (blockages in the blood flow to the heart) with adenosine tracer scans. Adenosine is a drug used routinely in patients to relax heart blood vessels in order to assess for the presence of coronary artery disease. Often, if patients have had caffeine, the adenosine scan is not used because of the belief that caffeine may reduce the ability to detect coronary artery disease. We would like to test whether caffeine affects our ability to detect coronary artery disease with adenosine tracer scanning. We will perform an imaging study of the heart with adenosine after you have received caffeine.

Detailed Description

Not available

Study Timeline

• Study Start: 1999-06
• Primary Completion: 2004-12
• Study Completion: 2004-12
• Study First Submitted: 2005-09-12
• Study First Submitted QC: 2005-09-13
• Study First Posted: 2005-09-20
• Status Verified: 2012-10
• Last Update Submitted: 2012-10-25
• Last Update Posted: 2012-10-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Patients who have already completed rest/stress 99mTc sestamibi or 99mTc tetrofosmin imaging will be given a form describing this protocol and asked to volunteer for the additional scan

Exclusion Criteria

• history of asthma, bronchospastic COPD, or renal failure

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
2	Cardiac SPECT imaging Rest and Stress	Caffeine 200 mg po one hour before adenosine infusion
1	Cardiac SPECT imaging Rest and Stress	Caffeine 400 mg PO 1 hour before adenosine infusion
1	Caffeine	Caffeine 400 mg PO 1 hour before adenosine infusion
2	Caffeine	Caffeine 200 mg po one hour before adenosine infusion

Primary Outcome Measures

Name	Time	Method
This protocol has a specific aim of determining whether prior caffeine administration affects the sensitivity and specificity of adenosine perfusion scintigraphy for detection of impaired coronary vascular reserve.	Assessment is made at the time of research adenosine perfusion scintigraphy

Secondary Outcome Measures

Name	Time	Method
determination of caffeine levels in patients instructed to hold caffeine prior to adenosine imaging	Assess at time of lab sample results obtained

Trial Locations

Locations (1)

University of Wisconsin; 🇺🇸 Madison, Wisconsin, United States