Caffeine and the Autonomic Nervous System

Not Applicable

• Conditions: Autonomic Nervous System Imbalance
• Interventions: Dietary Supplement: caffeine

• Registration Number: NCT04886869
• Lead Sponsor: LMU Klinikum

Brief Summary

Caffeine consumption has been linked to dysfunction of the autonomic nervous system. In this study the investigators analyze the effects of caffeine containing drinks (including energy drinks and coffee) on ECG based parameters of the autonomic nervous system.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-04-01
• Study First Submitted: 2021-04-30
• Status Verified: 2021-05
• Study First Submitted QC: 2021-05-10
• Last Update Submitted: 2021-05-10
• Study First Posted: 2021-05-14
• Last Update Posted: 2021-05-14
• Primary Completion: 2021-06-30
• Study Completion: 2021-06-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• healthy individuals
• > 18 years

Exclusion Criteria

• known cardiovascular disease
• other diseases which may influence the autonomic nervous system
• medication which may influence the autonomic nervous system
• prior caffeine consumption (<24 hours)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
Coffee	caffeine	Oral consumption of 3 cups of coffee containing 240 mg caffeine
Energy drink	caffeine	Oral consumption of 750 mL of a commercial energy drink containing 240 mg caffeine
Placebo	caffeine	Oral consumption of 750 mL water

Primary Outcome Measures

Name	Time	Method
Heart rate (HR)	2 hours	ECG-based analysis of heart rate (beats per minute)

Secondary Outcome Measures

Name	Time	Method
Periodic repolarization dynamics (PRD)	2 hours	ECG-based analysis of repolarization instability (deg²)

Trial Locations

Locations (1)

University Hospital Munich (LMU Klinikum); 🇩🇪 Munich, Germany