If chronic depressive patients choose their treatment... Psychoanalytic and cognitive-behavioural long-term treatment for chronic depressio

Not Applicable

Completed

• Conditions: Chronic major depression in outpatient care; Mental and Behavioural Disorders; Depressive episode

• Registration Number: ISRCTN91956346
• Lead Sponsor: German Society for Psychoanalysis, Psychotherapy, Psychosomatics and Depth Psychology (DGPT) (Germany)

Brief Summary

2012 Protocol article in http://www.ncbi.nlm.nih.gov/pubmed/22834725 protocol 2019 Results article in https://pubmed.ncbi.nlm.nih.gov/30384775 results (added 14/02/2020) 2024 Results article in https://pubmed.ncbi.nlm.nih.gov/39119997/ (added 12/08/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2009-07-10
• Study Completion: 2019-02-24
• Last Update Posted: 26 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 252

Inclusion Criteria

1. Both males and females, age range 21 - 60 years
2. Major depression (by SKID I, the German version of Structural Clinical Interview I [SCID I]) and/or dysthymia (by SKID I)
3. Complaints for at least 12 month
4. Quick Inventory of Depressive Symptomatology - clinician rating (QIDS-C) greater than 9
5. Beck Depression Inventory II (BDI II) greater than 17
6. Sufficent knowlege of the German language
7. No restriction of intellectual capacity
8. Consent to the study protocol, secrecy containment to the treating physician

Exclusion Criteria

1. Current or in the case history psychotic symptomatology, schizoaffective, schizophrenic or bipolar affective disorder
2. Substance dependence current or during the last 3 years
3. Dementia
4. Borderline, schizotypal and antisocial personality disorder
5. Acute suicidality
6. Serious physical illness that strongly affects the depression or is causally for the depression

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Depressive sympomatology, assessed with BDI 2 and QIDS-C at pre- and post-treatment. Treatment response is defined as at least 50% decrease in BDI 2 and QIDS-C scores.<br>2. Remission, defined as a QIDS-C score of less than 6<br>3. SKID<br>4. Operational psychodynamic diagnosis (Operationalisierte Psychodynamische Diagnostik) (OPD2)<br><br>All primary and secondary outcomes will be assessed at the initial examination (t0) and after 1, 2 and 3 years of treatment.

Secondary Outcome Measures

Name	Time	Method
1. Symptom Checklist-90-R (SCL-90-R)<br>2. Social and Occupational Functioning Assessment Scale (SOFAS)<br>3. Depressive Experiences Questionnaire (DEQ)<br>4. Reduction in health costs, assessed using health insurance data<br><br>All primary and secondary outcomes will be assessed at the initial examination (t0) and after 1, 2 and 3 years of treatment.