NCT04478877已完成不适用
Establishment and Characterization of Meningioma Patient-derived Organoids
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Whole exome sequencing data
研究概览
简要总结
In this study, meningioma organoids will be established from patients' tissues and the characterization of the organoid will be performed.
详细描述
Aims and Hypothesis to be tested:
The investigators hypothesized that the derived organoid should have a similar morphological and genetic mutation signatures to the patient primary tissue.
Study period: 1 year for patient recruitment and organoid generation from patient tumor
Study population: 30
Study samples:
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (aged >18 years) with meningioma
- •Admission into Prince Wales hospitals neurosurgical services
- •Patients with surgical needs of meningioma removal
排除标准
- •Patients (or next-of-kin as appropriate) refuse to participate into the study
结局指标
主要结局
Whole exome sequencing data
时间窗: 7 days
DNA extracted from patient tumor tissue and patients-derived organoids will be perform whole exome sequencing for genetic characterization.
次要结局
- Immunostaining(7 days)
研究者
George KC Wong
Clinical Professor
Chinese University of Hong Kong
研究点 (1)
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