Generation of Organoids of Neuroendocrine Neoplasms of the Gastro-Entero-Pancreatic Tract Obtained From Patients Undergoing Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Gastro-entero-pancreatic Neoplasms
- Sponsor
- Regina Elena Cancer Institute
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Set up of at least 10 organoid cultures
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
Observational, prospective, feasibility pilot study of the preparation of organoids starting from tumor tissue and surrounding healthy tissue, collected during surgery, performed according to standard clinical practice.
Detailed Description
Given the need for the use of experimental models that mimic the tumor of origin
Investigators
Eligibility Criteria
Inclusion Criteria
- •over 18 years of age;
- •diagnosis of GEP-NEN carried out via histological investigation or via positivity to the uptake PET-CT with 68Ga-peptides;
- •availability of adequate material for the preparation of organoid cultures, derived from surgery;
- •written informed consent.
Exclusion Criteria
- •previous chemotherapy treatments
Outcomes
Primary Outcomes
Set up of at least 10 organoid cultures
Time Frame: 42 months
The organoids will be generated from tumor tissue samples and surrounding healthy tissue obtained from patients affected by GEP-NEN (who meet the inclusion/exclusion criteria) collected, according to clinical practice, during tumor resection surgery. Only the excess material after carrying out all the investigations necessary for the correct diagnosis histological analysis can be used for the purpose of the project