eural and structural adaptation of human skeletal muscle to overstretch and overload through mechanical stimuli delivered by dynamometry and exoskeletons
- Conditions
- spinal cord injurystroke1002830210029317
- Registration Number
- NL-OMON51207
- Lead Sponsor
- niversity of Twente
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 30
- Age between 18 and 55,
- legal capacity to give their consent at their own will
- neuromuscular disease,
- carrier of infectious diseases (COVID19),
- degenerative mental impairment, e.g. dementia,
- inability to cooperate, e.g. due to cognitive deficits (in understanding
instructions) or a level of motor impairment that does not permit execution of
the intended tasks,
- subjects suffering from known cardiac conditions (e.g., pacemakers,
arrhythmias, and cardiac conduction disturbances) or peripheral neuropathy.
- skin sensitivity or allergies as these are typical contraindications for the
application of surface EMG electrodes via adhesive elements and conductive gels.
- If participants have one of the following objects in their bodies: metal
(splinters) (e.g., by working in the metal industry); pacemaker, pacemaker
leads or an implanted defibrillator; an artificial heart valve/aorta valve or a
stent; clips on blood vessels; implanted magnets in the jaw; fixed hearing aid,
bladder stimulator, insulin pump, neurostimulator, baclofen pump, tissue
expander; eye or ear implants; foreign materials implanted in the body; braces
or metallic wire fixed behind teeth; piercings. Participants with these objects
in/on their bodies have to be excluded as they must not be inside of a magnetic
resonance imaging device
- Dependency on one or more researchers of this project
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome of this study will be to relate muscle volume, fascicle<br /><br>length, and pennation angle to motor unit discharge rate, inter-spike interval,<br /><br>and recruitment threshold. </p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary outcome of this study will be to compare muscle fascicle length<br /><br>changes and shortening velocity, and motor neuron discharge rate, inter-spike<br /><br>interval, and recruitment threshold before and after the training intervention.</p><br>