Comparison of Efficacy Between Cold Snare Polypectomy and Endoscopic Mucosal Resection in Treatment of Small Polyp
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Asan Medical Center
- Enrollment
- 103
- Locations
- 1
- Primary Endpoint
- complete resection rate (CRR)
Study Overview
Brief Summary
The investigators will investigate the efficacy of EMR compared to CSP in treatment of small colon polp (6~10mm).
One aim of this study was to investigate the necessity of EMR on resection of small colon polyp.
Detailed Description
With sized polyp from 6mm to less than 10mm, it has been classified by the previous studies as a "small polyp".
Their potential for advanced neoplasia is usually size-dependent, but some recent studies found that, even in diminutive and small polyps, the rate of advanced neoplasia is relatively high about 9%-10%.
The investigators will prospectively investigate postprocedural outcomes, such as retrieval rate, procedural time, overall complication rate (Intraprocedural bleeding, postprocedural bleeding, and perforation) in colonoscopic polypectomy of small polyp between CSP and EMR.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 20 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •All those over the age of 20 years who agree informed consent and who have at least one polyp of eligible size (6-10 mm)
Exclusion Criteria
- •(1) patients taking anticoagulant therapy during the past 1 week of the procedure, (2) known coagulopathy, (3) history of liver cirrhosis, chronic kidney disease, malignancy, inflammatory bowel diseases or significant infectious disease, (4) American Society of Anesthesiology class III or more, and (5) pedunculated polyps and polyps with malignant feature.
Arms & Interventions
Cold snare polypectomy
CSP will be performed by closing the snare loop after positioning the open snare at the point of lesion.
Intervention: CSP (Other)
Endoscopic mucosal resection
EMR will be performed in the way of drawing the lesion into the loop of the snare and resecting followed by saline injection to the its margin.
Intervention: EMR (Other)
Outcomes
Primary Outcomes
complete resection rate (CRR)
Time Frame: Up to 2 months
Secondary Outcomes
- incidence of complications (Intraprocedural bleeding, postprocedural bleeding, and perforation)(Up to 2 months)
- necessity of hemostasis (due to Intraprocedural bleeding or postprocedural bleeding)(Up to 2 months)
- Polyp retrieval rate(Up to 2 months)
- hospitalization period(Up to 2 months)
Investigators
Jeong-Sik Byeon
Professor
Asan Medical Center