Possible Pharmacological Effect of Quercetin in the Management of Hyperuricemia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 161
- 试验地点
- 1
- 主要终点
- Change in plasma uric acid level
研究概览
简要总结
Quercetin, a natural flavonoid found in various fruits and vegetables, has gained attention for its potential role in managing hyperuricemia. Emerging evidence suggests that quercetin may reduce plasma uric acid levels by inhibiting xanthine oxidase, an enzyme responsible for uric acid production. Additionally, its anti-inflammatory and antioxidant properties could help mitigate the oxidative stress and inflammation associated with hyperuricemia. As a result, quercetin supplementation offers a promising avenue for therapeutic intervention in conditions like gout and other uric acid-related disorders.
详细描述
In the present retrospective cross-sectional observational study, the investigators assessed the potential pharmacological effect of supplemental quercetin on the plasma uric acid levels of health adults. These participants visited nutritional clinics in Italy during the Coronavirus disease (COVID-19) pandemic for general health check-up in real-life to enhance their immune system with supplements aimed at providing additional protection against COVID-19 infection. The supplements, either quercetin or probiotic Streptococcus salivarius K12 (BLIS K12), were advised randomly to the participants for 90 days, tailored to individual needs and in the absence of any pre-defined criteria.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adults
- •BMI between 18.5 and 29.9 kg/m²
- •Non-smoker
- •Consumtion of less than 3 units of alcohol per day
排除标准
- •- Plasma uric acid concentrations above 7 mg/dL
- •Diagnosis of endocrinological, metabolic, oncological, neurological, or bowel inflammatory disease diseases, gout, kidney stones
结局指标
主要结局
Change in plasma uric acid level
时间窗: 90 days
Supplement effect on plasma uric acid level
次要结局
- Change in plasma cholesterol level(90 days)
- Change in plasma triglycerides level(90 days)
- Change in plasma glucose level(90 days)
- Change in plasma insulin level(90 days)
- Change in plasma creatine phosphokinase level(90 days)
- Change in alanine transaminase level(90 days)
- Change in aspartate aminotransferase level(90 days)
- Change in alkaline phosphatase level(90 days)
- Change in gamma-glutamyl transferase level(90 days)
- Change in bilirubin level(90 days)
- Incidence of side effects(90 days)
研究者
Dr. Amjad Khan
Professor of Clinical Biochemistry and Experimental Medicine
Liaquat University of Medical & Health Sciences