Effect of Quercetin in Prevention and Treatment of Oral Mucositis

Phase 1

Completed

• Conditions: Chemotherapy Induced Oral Mucositis
• Interventions: Drug: Placebo; Drug: oral quercetin capsules

• Registration Number: NCT01732393
• Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary

The study aims to evaluate the effect of Quercetin (a natural flavonoid) on prevention of and treatment of chemotherapy-induced oral mucositis in patients with blood malignancies.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01
• Primary Completion: 2011-10
• Study Completion: 2012-01
• Study First Submitted: 2012-11-19
• Study First Submitted QC: 2012-11-21
• Study First Posted: 2012-11-22
• Status Verified: 2012-12
• Last Update Submitted: 2012-12-04
• Last Update Posted: 2012-12-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• patient under chemotherapy
• for a hematologic malignancy
• the hematologist permits the trial on the patient
• agreement of patient for participating in the trial

Exclusion Criteria

• presence pf ANY oral lesion at the beginning of the trial
• loss of follow up
• use of digoxin and cyclosporine
• patient death

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
oral placebo capsules	Placebo	Patients in the placebo group received two placebo capsules containing lactose .
oral quercetin capsules	oral quercetin capsules	Patients in the intervention group were administered two, 250 mg Quercetin capsules daily for 3 weeks

Primary Outcome Measures

Name	Time	Method
lower grade of mucositis	3 weeks	grade of mucositis due to WHO criteria

Secondary Outcome Measures

Name	Time	Method
duration of mucositis	3 weeks of study tiem span and after trial	duration of mucositis due to Who criteria

Trial Locations

Locations (1)

Oral Medicine Department of Mashhad dental School; 🇮🇷 MAshhad, Khorasan Razavi, Iran, Islamic Republic of