NCT01732393已完成1 期
Effect of Quercetin in Prevention and Treatment of Chemotherapy Induced Oral Mucositis in Blood Dyscrasias
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- lower grade of mucositis
研究概览
简要总结
The study aims to evaluate the effect of Quercetin (a natural flavonoid) on prevention of and treatment of chemotherapy-induced oral mucositis in patients with blood malignancies.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 15 Years 至 40 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient under chemotherapy
- •for a hematologic malignancy
- •the hematologist permits the trial on the patient
- •agreement of patient for participating in the trial
排除标准
- •presence pf ANY oral lesion at the beginning of the trial
- •loss of follow up
- •use of digoxin and cyclosporine
- •patient death
研究组 & 干预措施
oral quercetin capsules
Active Comparator
Patients in the intervention group were administered two, 250 mg Quercetin capsules daily for 3 weeks
干预措施: oral quercetin capsules (Drug)
oral placebo capsules
Placebo Comparator
Patients in the placebo group received two placebo capsules containing lactose .
干预措施: Placebo (Drug)
结局指标
主要结局
lower grade of mucositis
时间窗: 3 weeks
grade of mucositis due to WHO criteria
次要结局
- duration of mucositis(3 weeks of study tiem span and after trial)
研究者
Pegah Mosannen Mozafari
assistant professor of oral medicine
Mashhad University of Medical Sciences
研究点 (1)
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