Use of Quercetin to Increase Resiliency to Palmitic Acid in the Human Microvasculature
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Change in blood vessel dilation
研究概览
简要总结
The goal of this study is to learn how a supplement Quercetin can affect microvascular function.
Participants will:
- give two blood draws of 5 mL each
- have a camera placed under the tongue to take pictures of blood vessels
- have 2 laser Doppler microdialysis catheters placed on the forearm to monitor blood vessels before and after local drug infusion
Researchers will compare blood vessel function of those who take estrogen supplements to those who do not.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Obesity (BMI>30)
- •Aged 18-40 years
- •English Speaking
排除标准
- •Resting SBP ≥180 mmHg or DBP ≥ 110mmHg
- •Pregnancy or breastfeeding.
- •Prior history of myocardial infarction
- •Diagnosis of more than 1 risk factor for coronary artery disease (active smoker, diabetes mellitus- type 1 or 2, congestive heart failure, hyperlipidemia, hypertension)
- •Active mouth sores that affect the buccal mucosa.
研究组 & 干预措施
Use of oral quercetin to improve human microvascular function
Quercetin is a non-FDA approved, over-the-counter supplement that has been shown to improve oxidative capacity in blood vessels.
干预措施: Quercetin (dietary supplement) (Dietary Supplement)
Placebo
A placebo will be administered for 30 days followed by assessment of the subject's microvascular function.
干预措施: Placebo (Drug)
结局指标
主要结局
Change in blood vessel dilation
时间窗: 2 hours
Peripheral microvascular dilation in response to acetylcholine, L-NAME, and sodium nitroprusside infusions will be measured using laser Doppler flowmetry with microdialysis.
次要结局
- Change in Perfused Vessel Density(0.5 hours)
研究者
Julie K. Freed
Executive Vice Chair
Medical College of Wisconsin