Acute effect of coconut oil on peak forearm blood flow in healthy men: A randomised crossover trial
- Conditions
- Healthy young menVirgin coconut oil, Peak forearm blood flow, Vascular function, Saturated fatty acid, Medium chain triglyceride
- Registration Number
- TCTR20210807001
- Lead Sponsor
- Research affairs, Faculty of Medicine, Chulalongkorn University
- Brief Summary
Coconut oil augmented vascular function in healthy young men by increasing FBFpeak despite the accompanying postprandial elevations of plasma triglycerides and free fatty acids.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Male
- Target Recruitment
- 17
Inclusion criteria were being healthy and physically inactive. Being healthy in the present study was defined as non-smoking, normotensive with a blood pressure below 120 over 80 mmHg, normal resting electrocardiogram (EKG), normal body mass index (BMI)below 23 kg/m2, normolipidemic
with a fasting triglycerides of less than 150 mg/dL, cholesterol of less than 200 mg/dL, and a low-density lipoprotein (LDL) cholesterol of less than 130 mg/dL, and non-diabetic with a fasting blood glucose of less than 100 mg/dL. Physically inactive was defined as engaging in sports or regular physical exercise at moderate intensity such as jogging, cycling, or recreational sports of no longer than 30 minutes per session, less than three sessions per week for the past three months
Exclusion criteria were open wound on upper extremities, musculoskeletal or nervous system abnormalities, unable to ingest coconut oil, and taking antioxidants or vitamins supplements within one week prior to the experiments
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Peak forearm blood flow baseline, 2 hr. and 4 hr. after the experiment (ml/100 ml tissue.minute)/An automatic venous occlusion strain gauge plethysmography (EC6, D.E. Hokanson Inc., USA)
- Secondary Outcome Measures
Name Time Method Vascular resistance baseline, 2 hr. and 4 hr. after the experiment Arbitrary unit (u)/An automatic blood pressure measurement cuff (BSM 6000 series, Nikon Kohden),Triglyceride baseline, 2 hr. and 4 hr. after the experiment (mg/dl)/Colorimetry technique using the Architect C system (Abbott Diagnosis) ,Free fatty acids baseline, 2 hr. and 4 hr. after the experiment (uEq/l)/ NEFA C quantification kit (Wako, Osaka, Japan) ,Malondialdehyde baseline, 2 hr. and 4 hr. after the experiment (umol/dl)/ Thiobarbituric acid-reactivesubstances reaction and the colorimetric absorbance technique