Motivational Behavioral and Functional MRI Impairment in Patients With Chronic Neuropathic Pain
Not yet recruiting
- Conditions
- Chronic Pain
- Interventions
- Other: reward learning task
- Registration Number
- NCT05701852
- Lead Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
- Brief Summary
The main hypothesis of this study is that the alteration of the reward circuitry underlying the motivational deficit in chronic pain patients compared to healthy subjects results in a decrease in the capacity for reward learning. The fMRI studies have shown that this type of learning depends on the dopaminergic system innervating key regions of the reward system.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- For cases: patients managed in the neurosurgery department or at CETD for chronic neuropathic pain, of central or peripheral origin.
- For controls: matched to a case on age (±5 years) and sex
Exclusion Criteria
- Neurodegenerative or inflammatory neurological pathology
- Clinical depressive syndrome
- High doses of opioid treatment (greater than 100 mg/day of morphine equivalent)
- Impaired judgment or inability to receive information that does not allow the performance of behavioral tasks
- Absolute contraindication to MRI (e.g. pacemaker, implantable pacemaker, metallic intra-orbital foreign body)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description cases : patients with chronic pain reward learning task - controls reward learning task -
- Primary Outcome Measures
Name Time Method To compare reward learning ability in patients with chronic neuropathic pain compared with an age (±5 years) and gender-matched control population Day 0 the reward learning ability will be assessed using a specific task. The result of the task questionnaire is a numeric score.
- Secondary Outcome Measures
Name Time Method