A Randomized Trial Comparing the Effect of Immediate Versus Delayed Frozen-thawed Embryo Transfer Following a Stimulated IVF Cycle
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 724
- 试验地点
- 1
- 主要终点
- ongoing pregnancy
研究概览
简要总结
Information regarding the optimal timing for frozen-thawed embryo transfer (FET) following a stimulated in vitro fertilization (IVF) is lacking. One option is to perform FET in the first cycle following the stimulated IVF cycle, i.e. immediate transfer. Another option is to postpone FET for at least one menstrual cycle, i.e. delayed transfer. This randomized study aims to compare the ongoing pregnancy rate of immediate versus delayed FET following a stimulated IVF cycle.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
盲法说明
No masking because of the nature of the intervention
入排标准
- 年龄范围
- 20 Years 至 43 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women aged ≤43 years at the time of IVF/ICSI treatment Undergoing IVF with a standard stimulation At least one frozen embryo or blastocyst The first FET cycle following ovarian stimulation in IVF/ICSI
排除标准
- •Use of mild stimulation or natural cycle for IVF/ICSI treatment Severe ovarian hyperstimulation syndrome during IVF/ICSI treatment Preimplantation genetic diagnosis treatment Use of donor oocytes Presence of hydrosalpinx which is not surgically treated or endometrial polyp on scanning during ovarian stimulation
研究组 & 干预措施
immediate group
the intervention: immediate frozen-thawed embryo transfer (FET) which means FET will be performed in the first cycle following the stimulated IVF cycle
干预措施: immediate frozen-thawed embryo transfer (Other)
delayed group
the intervention: delayed frozen-thawed embryo transfer (FET) which means FET will be performed at least in the second cycle following the stimulated IVF cycle
干预措施: delayed frozen-thawed embryo transfer (Other)
结局指标
主要结局
ongoing pregnancy
时间窗: viable pregnancy beyond gestation 12 weeks
viable pregnancy beyond gestation 12 weeks
次要结局
- miscarriage(the loss of a pregnancy before 22 weeks gestation)
- Positive hCG level(A blood pregnancy test is performed 14 days after the FET)
- clinical pregnancy(presence of intrauterine gestational sac on ultrasound at 6 weeks of pregnancy)
- biochemical pregnancy:(positive blood pregnancy test not followed by clinical pregnancy during 12 weeks gestation)
- implantation rate(number of gestational sacs per embryo transferred during 4 weeks of pregnancy)
- multiple pregnancy(multiple pregnancy beyond gestation 12 weeks)
- ectopic pregnancy(ectopic pregnancy during 12 weeks gestation)
- live birth rate(a live birth after 22 weeks gestation)
- birth weight(a live birth after 22 weeks gestation)