NCT01298297已完成4 期
Comparison of Sublingual Buprenorphine With Intravenous Morphine Sulfate in Treatment of Acute Pain Due to Long Bone Fracture
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Change in pain severity/score
研究概览
简要总结
The purpose of this study is to determine whether sublingual buprenorphine is effective in the treatment of acute pain in adult patients with extremity bone fractures
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of extremity bone fracture Age>16 years Acute pain of score 3 or greater on numerical rating scale
排除标准
- •Long term use of opium or opioids/dependence Previous administration of analgesic Known sensitivity to opioids Pregnant women History of medical problems (liver, kidney, heart, hematologic)
研究组 & 干预措施
Buprenorphine + Placebo
Active Comparator
干预措施: Buprenorphine (Drug)
Morphine + Placebo
Placebo Comparator
干预措施: Morphine (Drug)
结局指标
主要结局
Change in pain severity/score
时间窗: After 60 min
次要结局
- Need for rescue analgesia(After 60 min)
- Occurrence of adverse events(During 60 min)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
2 期
Comparison of sublingual buprenorphine and intravenous morphine in pain relief and side effects in patients with primary headache admitted in emergency departmentHeadache.Migraine, Tension-type headache, Cluster headache syndromeG44.2 ,G4IRCT2015030821379N1Vice chancellor for research of Ahwaz University of Medical Sciences140
已完成
不适用
Comparison of Sublingual buprenorphine and intravenous morphine for postoperative analgesic effect hemodynamic changes, nausea & vomitingSpinal anesthesia in ASA ClassI, II.Other complications of anaesthesiaOther compIRCT201012203305N2Vice-chancellor for Research, Babol University Of Medical Sciences100
已完成
2 期
Comparison of Buprenorphine to Morphine in Treatment of Neonatal Abstinence Syndrome (NAS)Neonatal Abstinence SyndromeNeonatal Withdrawal SyndromeNCT01708707Pediatrix29
已完成
不适用
The comparison of Buprenorphine and Ketorolac Analgesic Effect in Patients with Renal ColicRenal colic.urinary calculus, unspecifiedIRCT2015041421773N1Department of Assistance Research- Jundishapour University of Medical Sciences62
已完成
3 期
The Safety and Efficacy of the Buprenorphine Transdermal Delivery System in Subjects With Chronic Back Pain.Chronic Low Back PainNCT00315887Purdue Pharma LP250