JPRN-UMIN000017994已完成未知
ocalization of specialized intestinal metaplasia and the molecular alterations in Barrett's esophagus in a Japanese population: an analysis of biopsy samples based on the "Seattle" biopsy protocol - Phenotypic and molecular localization of BE
Division of Gastroenterology, Hyogo College of Medicine0 个研究点目标入组 30 人开始时间: 2015年6月21日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 30
研究概览
简要总结
- MSI and hypermethylation at RUNX3, MGMT, hMLH1, p16 and APC genes were associated with BE carcinogenesis, but only APC gene hypermethylation was an independent predictive marker of EAC (OR=24.4, p=0.01) in the multivariate logistic regression analysis. In addition, the incidence of the these biomarkers did not show a significant difference between the 0-3 o'clock and 6-9 o'clock areas. 2. SIM was more frequently identified in the 0-3 o'clock quadrant than in the 6-9 o'clock quadrant (p=0.08). 3. The Ki-67 index was higher in SIM than in the columnar-lined epithelium (CLE) without goblet cells (p<0.0001), and in both SIM and CLE with Das-1 reactivity than in those without (p=0.04 and p=0.06, respectively). 4. The Ki-67 index was relatively higher in the 0-3 o'clock quadrant than in the 6-9 o'clock quadrant in cases with Das-1 reactivity.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- ot applicable 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •(1) Patients with a history of esophagectomy or gastrectomy (2) Patients having no application to the guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment from Japan Gastroenterological Endoscopy Society (3) Patients who have determined by the physicians to have any reasons of unqualified
研究者
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