Contrast enhanced Magnetic Resonance Imaging of the lungs in children with Cystic Fibrosis.
Completed
- Conditions
- 10038716mucoviscoidosis
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
inclusion criteria: signed informed consent, able to comply with protocol requirements, diagnosis of CF confirmed, age 6-18 years, stable condition, ability to perform lung function tests and breathhold manoeuvres, CT in the year before the MRI.
Exclusion Criteria
inability to follow instructions of the investigator, current respiratory infection requiring IV antibiotics, pulmonary complications that might put patient at risk to participate , claustrophobia, history of anaphylactic reaction on contrast agent, any clinical condition which, according to the treating physician, might put patient at risk, severe asthma and/or severe allergies as determined by physician.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The ability of the radiologist and CF team to identify areas of the lung that<br /><br>are hypo perfused on the Gd-MRI relative to the proton-MRI.<br /><br>The distribution and volume of hypo perfused lung on the Gd-MRI will be<br /><br>compared to the distribution of trapped air on the proton-MRI and with the<br /><br>chest CT made in the previous year.<br /><br>After completion of the study all CTs and Gd-MRIs will be scored anonymous and<br /><br>in random order using a semi quantitative scoring system. </p><br>
- Secondary Outcome Measures
Name Time Method <p>The ability of the radiologist and CF team to identify progression of<br /><br>peripheral bronchiectasis compared to the CT made in the previous year. </p><br>