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Clinical Trials/NL-OMON54061
NL-OMON54061
Recruiting
N/A

Advanced Image Supported Left Ventricular Lead Placement in Cardiac Resynchronization Therapy III - ADVISE-III

niversitair Medisch Centrum Utrecht0 sites130 target enrollmentTBD

Overview

Phase
N/A
Intervention
Not specified
Conditions
Cardiomyopathy
Sponsor
niversitair Medisch Centrum Utrecht
Enrollment
130
Status
Recruiting
Last Updated
last year

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
last year
Study Type
Interventional

Investigators

Sponsor
niversitair Medisch Centrum Utrecht

Eligibility Criteria

Inclusion Criteria

  • An indication for cardiac resynchronization therapy according to the current
  • international evidence based guidelines for CRT (the 2016 European Society of
  • Cardiology Guidelines for Acute and Chronic Heart Failure:
  • \- Chronic heart failure;
  • \- New York Heart Association functional class II, III, IV (ambulatory);
  • \- QRS duration \>\=130ms;
  • \- Optimal pharmacological therapy;
  • \- Left ventricular ejection fraction \<\=35%;
  • \- Either a QRS duration \>\=130ms with left\-bundle branch block OR a QRS duration
  • \>\=150ms without left\-bundle branch block.

Exclusion Criteria

  • Contraindications for implantation of a CRT device;
  • \- Age \<18 years or incapacitated adult;
  • \- Pregnancy; if there is anamnestic doubt regarding postmenopausal state (\<1
  • year since last menstruation), a urine hCG test (Alere) will be performed.
  • \- Lactation;
  • \- Subjects with impaired renal function (severe renal insufficiency, GFR \< 30
  • ml/min/1\.73m2\);
  • \- Atrial fibrillation or atrial fibrillation during MRI
  • \- Documented allergic reaction to gadolinium;
  • \- Impossibility to undergo a MRI scan (determined by using the standard

Outcomes

Primary Outcomes

Not specified

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