Tackling underdiagnosis of Large Artery Giant Cell Arteritis: a prevalence and phenotype study.
Completed
- Conditions
- giant cell arteritislarge vessel vasculitis10047066
- Registration Number
- NL-OMON35072
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
Giant cell arteritis according to the 1990 ACR classification critieria, or
elevated ESR on 2 separate occasions with a time interval of at least 4 weeks, the elevated ESR is not explained by a chest radiograph, abdominal ultrasound or blood tests (including paraprotein testing)
Exclusion Criteria
The use of corticosteroids or any other systemic immunosuppresant for more than 24 hours at the time of PET-CT scanning. Inability to understand or unwillingness to provide informed consent. A plasma glucose level >11 mmol/l at the time of PET-CT scanning.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Prevalence of large-vessel-vasculitis in patients with temporal arteritis or<br /><br>unexplained prolonged inflammatory response.<br /><br>Diagnostic utility of PET/low-dose-CT in patients with an unexplained prolonged<br /><br>inflammatory response.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Association between large-vessel-vasculitis and clinical/biochemical parameters.<br /><br>Association between large-vessel-vasculitis and inflammation score of temporal<br /><br>artery biopsy.<br /><br>Sensitivity and specificity of temporal artery biopsy for<br /><br>large-vessel-vasculitis.<br /><br>Association between FDG-uptake and vessel wall morphology/lumen morphology.</p><br>