Surgery Versus Radiotherapy for Locally Advanced Prostate Cancer
- Conditions
- Prostatic Neoplasms
- Interventions
- Procedure: Prostatectomy/SurgeryOther: Radiotherapy with adjuvant androgen deprivation therapy
- Registration Number
- NCT02102477
- Lead Sponsor
- Olof Akre
- Brief Summary
This prospective, open randomized phase III surgical trial seeks to study whether radical prostatectomy (with or without the combination of external radiation) improves prostate-cancer specific survival in comparison with primary radiation treatment and hormonal treatment among patients diagnosed with locally advanced (T3) prostate cancer. Untreated or conservatively treated locally advanced prostate cancer is associated with high mortality. Modern curative treatment for advanced solid malign tumors include surgery and/or radiation plus attempted chemotherapy if available to achieve both local control and elimination of potential micro metastases. Whereas there is evidence that surgery can cure localized prostate cancer, there are no clinical trials of multi-modal treatment of locally advanced prostate cancer that includes surgical removal of the prostate.
One potential advantage of adding prostatectomy to the treatment of LAPC is that removing the prostate enables a full pathological assessment of the tumor characteristics and thus a better estimation of the risk of recurrence. Surgical treatment could thus reduce the numbers needed to treat with chemotherapy and radiation, and thus improve quality of life after treatment. In addition, evidence indicate that residual cancer in the prostate occurs in 25% after radiation treatment (56) and surgical removal of the prostate may improve survival beyond what can be achieved by radiation and ADT. On the other hand, patients treated with surgery, radiation and hormones will experience side effects of all three treatment modalities and might fare better if radiotherapy plus hormones can provide oncological control without prior surgery.
A randomized clinical trial comparing two multimodal treatment regimens of which one includes a radical prostatectomy is therefore warranted.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Male
- Target Recruitment
- 1200
- Age ≤75, at the time of randomization
- Diagnosed histopathologically confirmed and untreated prostatic adenocarcinoma
- The general condition and mental status of patients shall permit observation in accordance with the study protocol
- Tumor stage (T, M, N):
T3 stage (as indicated by digital rectal examination or MR imaging or other validated imaging technique) T4 tumors can be included if considered resectable/treatable on MR imaging Significant extra-capsular tumor extension in biopsy (rare but acceptable for inclusion) M0 (no sign of distant metastases) confirmed by bone scan or CT or MRT of axial skeleton (at a maximum of pelvis and lumbar vertebral column) N0 stage, defined in accordance to the RECIST guidelines as no sign of macroscopic retroperitoneal lymph-node metastases >=1.5 cm (short axis) on CT scan, PET-CT, or MRT or more than one suspected lymph-node metastases Presence Gleason grade pattern 4 or 5
- Signed Informed consent
- Patients with a PSA value of > 100 ng/mL
- Any medical condition that, in the opinion of the investigator, might interfere with the evaluation of the study objectives Patients with contraindications for either prostatectomy or radiotherapy to the prostate are not eligible for the study. Most contraindications for these treatments are relative, but in general, radiotherapy may be precluded among patients with:
- Anorectal disease, such as fistulae, Crohn´s disease, and ulcerative colitis
- Significant obstructive lower urinary tract symptoms
- Proximal stricture of the urethrae
- Severe neurogenic bladder dysfunction
- Enlarged prostate beyond 70-90 ml
- Previous radiotherapy to the pelvic region
On the other hand, surgery may be precluded among patients with:
- Massive local tumor progression, particularly in the apical region
- Massive abdominal obesity
- Contraindications to anesthesia
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Prostatectomy/Surgery Prostatectomy/Surgery Patients with locally advanced prostate adenocarcinoma recieves Prostatectomy/Surgery with or without adjuvant or salvage radiotherapy Radiotherapy with adjuvant androgen deprivation therapy Radiotherapy with adjuvant androgen deprivation therapy Patients with locally advanced prostate adenocarcinoma treated with adjuvant androgen deprivation therapy
- Primary Outcome Measures
Name Time Method Cause specific survival Up to 10 years Cause-specific survival (CSS) will be calculated as "1-cause specific mortality. Mortality and mortality causes will be ascertained from the nationwide Cause-of-Death Register. In the absence of a functioning Cause-of-Death register, an endpoint committee of at least 2 medical doctors will determine the cause of death.
- Secondary Outcome Measures
Name Time Method Metastasis free survival Up to 10 years Composite endpoint of time to metastasis and survival
Overall survival Up to 10 years Overall survival (OS) will be calculated as "1-overall mortality. Mortality data will be ascertained through the nationwide Cause-of-Death Register.
Cardiovascular disease Up to 10 years Data from national PcBaSe-register (https://snd.gu.se/en/catalogue/study/ext0014), a registry where the national prostate cancer registry (NPCR, www.npcr.se) has been linked to the Swedish National Cancer Register, the Cause of Death Register, the Prescribed Drug Register, the National Patient Register, and the Acute Myocardial Infarction Register, the Register of the Total Population, the Longitudinal Integration database for health insurance and labour market studies (LISA), the Multi-Generatioon Register and several other population-based registers.
Quality of life - general psychological, urinary, bowel and sexual health At 1,2,5 and 10 years after randomization Questionnaire-based evaluation of general psychological health, urinary health, bowel health, and sexual health.
Questions about self Questions about quality of life in the past month (scale 1 to 7; 1=no quality, 7=the best quality) Depression and anxiety (scale 1 to 7; 1=no, 7=very) Symptom Form (EPIC-26) (scale 1 to 5; 1= no problem, 5=major problem) Questions about the urinary tract Questions about sexual function Questions about bowel function Questions about prostate cancer - diagnosis and treatment Questions about prostate cancer check-ups Questions about hormone/castration therapy and its significance Questions about pain and lymph swellingTime to castration-resistant prostate cancer Up to 10 years Ascertained at follow-up visits
Time to biochemical progression Up to 10 years Ascertained at follow-up visits
Adverse events Up to 10 years Ascertained at visits
Trial Locations
- Locations (30)
Oslo University Hospital, Department of radiation Therapy
🇳🇴Oslo, Norway
St. Olavs Hospital
🇳🇴Trondheim, Norway
Oslo University Hospital, Department Urology
🇳🇴Oslo, Norway
University Hospital of North Norway
🇳🇴Tromsø, Norway
Turku University Hospital
🇫🇮Turku, Finland
Aalborg University Hospital
🇩🇰Aalborg, Denmark
Aarhus University Hospital
🇩🇰Aarhus, Denmark
Herlev Hospital
🇩🇰Herlev, Denmark
Rigshopsitalet Department urology
🇩🇰Copenhagen, Denmark
Rigshospitalet, Region h, Department Oncology
🇩🇰Copenhagen, Denmark
Helsinki University Hospital, Department of Urology
🇫🇮Helsinki, Finland
Odense University Hospital
🇩🇰Odense, Denmark
Tampere University Hospital, Pihlajalinna Koskiklinikka
🇫🇮Tampere, Finland
Sørlandet Hospital
🇳🇴Kristiansand, Norway
Falu Lasarett
🇸🇪Falun, Sweden
Sahlgrenska University Hospital
🇸🇪Göteborg, Sweden
Länssjukhuset Ryhov
🇸🇪Jönköping, Sweden
Helsingborgs Lasarett
🇸🇪Helsingborg, Sweden
Kirurgkliniken, Blekingesjukhuset
🇸🇪Karlskrona, Sweden
Linköping University Hospital
🇸🇪Linköping, Sweden
Skåne University Hospital
🇸🇪Malmö, Sweden
Karolinska University Hospital
🇸🇪Stockholm, Sweden
Umeå University Hospital
🇸🇪Umeå, Sweden
Vrinevis Hospital
🇸🇪Norrköping, Sweden
Capio St Göran Hospital
🇸🇪Stockholm, Sweden
Sundvalls Hospital
🇸🇪Sundsvall, Sweden
Uppsala Akademiska Hospital
🇸🇪Uppsala, Sweden
Centrallasarettet
🇸🇪Växjö, Sweden
Centrallasarettet Växjö Hospital
🇸🇪Växjö, Sweden
Östersund Hospital
🇸🇪Östersund, Sweden