Effect of Ketamine Added to Intravenous Patient-controlled Analgesia on Postoperative Pain, Nausea and Vomiting in Patients Undergoing Lumbar Spinal Surgery

Phase 4

Completed

• Conditions: Postoperative Nausea and Vomiting
• Interventions: Drug: Saline; Drug: Ketamine

• Registration Number: NCT01394406
• Lead Sponsor: Yonsei University

Brief Summary

Ketamine added to intravenous patient-controlled analgesia may be effective on prevention of postoperative nausea and vomiting by reducing opioid requirement after surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01
• Study First Submitted: 2011-07-13
• Study First Submitted QC: 2011-07-13
• Study First Posted: 2011-07-14
• Primary Completion: 2012-04
• Study Completion: 2012-04
• Status Verified: 2014-03
• Last Update Submitted: 2014-03-04
• Last Update Posted: 2014-03-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Non-smoking female patients undergoing elective lumbar spinal surgery
• Age 20-65
• American Society of Anesthesiologists physical status classification I or II

Exclusion Criteria

• Antiemetic within 24 hrs, Taking Steroids, Opioids within 1 week
• Psychiatric disease, Active drug or alcohol abuse
• GI motility disorder, severe renal/ hepatic disease
• insulin-dependent DM
• admission to ICU after surgery

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Saline group	Saline	-
Ketamine group	Ketamine	-

Primary Outcome Measures

Name	Time	Method
Incidence of postoperative nausea and vomiting	within 48 hrs after surgery

Trial Locations

Locations (1)

Severance Hospital; 🇰🇷 Seoul, Korea, Republic of