Dopaminergic Function and Food Reward

Completed

• Conditions: Adiposity; Weight Loss
• Interventions: Dietary Supplement: Dopamine depletion vs. Balanced aminoacid drink

• Registration Number: NCT01906411
• Lead Sponsor: University Hospital Tuebingen

Brief Summary

The broad aim of the study is to obtain a better understanding of alterations in mesolimbic reward pathways in adiposity based on the hypothesis of a hypofunctioning reward system in obesity.

This will be achieved by integrating a functional neuroimaging (fMRI) with behavioral reward tasks and the modulation of the dopamine level by dopamine depletion.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-07-08
• Study First Submitted QC: 2013-07-19
• Study First Posted: 2013-07-24
• Primary Completion: 2014-03
• Status Verified: 2015-05
• Last Update Submitted: 2015-05-28
• Last Update Posted: 2015-05-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 36

Inclusion Criteria

• female
• healthy

Exclusion Criteria

• fMRI contraindications
• claustrophobia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
subjecst with different BMI	Dopamine depletion vs. Balanced aminoacid drink	-

Primary Outcome Measures

Name	Time	Method
Differential brain functions in the dopaminergic reward system	4 hours after intake of the dopamine depletion or balanced aminoacid drink	differential brain fuctions will be measured by blood oxygen level dependent effect.

Secondary Outcome Measures

Name	Time	Method
amino acid level changes due to dopamine depletion	4 hours after intake of the dopamine depletion or balanced aminoacid drink

Trial Locations

Locations (1)

University Clinic of Tuebingen, MEG Center; 🇩🇪 Tuebingen, Germany