Investigation of improved nasal high flow to enhance carbon dioxide (CO2) clearance and maintain oxygen saturation during shared airway surgery

Not Applicable

Recruiting

• Conditions: Destauration/oxygenation during anaesthesia; airway management; Anaesthesiology - Anaesthetics

• Registration Number: ACTRN12619000613101
• Lead Sponsor: Fisher & Paykel Healthcare

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-04-24
• Last Update Posted: 8 July 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• 18 years and over and less than 80 years in age
• Capable of informed consent
• Undergoing laryngotrachael surgery under general anaesthetic expected to last at least 15 minutes

Exclusion Criteria

•BMI > 35 kg/m2.
•Patients who are deemed unfit for general anaesthesia and/or THRIVE treatment by the anaesthetist.
•Room-air saturation levels <85%
•requiring preoperative oxygen therapy secondary to chronic lung disease
•Pre-existing hypoxemia
•clinically-defined severe concomitant lower airway pulmonary disease
•Known contraindication to Optiflow™ device
•Patients in whom CPAP is contraindicated (e.g. pneumothorax, bullous lung disease, craniofacial trauma, airway, foreign body, unstable haemodynamics)
•history or symptoms of increased intracranial pressure or reduced intracranial compliance ( e.g. headaches, nausea and vomiting, visual changes, mental changes) .
•skull base defects.
•Patients in whom high FiO2 is contraindicated (e.g. patients being treated with Bleomycin)
•Patients undergoing procedures with electrocautery or laser.
•More than 50% (as judged by the anaesthetist) of the nares occluded by the nasal prongs
•Bleeding in nose or oropharynx
•Patients receiving an induction with volatile anaesthetics
•Patients with delicate skin that could be thermally damaged by the transcutaneous monitor

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in arterial CO2 from baseline as measured by arterial blood gas sample during shared airway surgery over the period 5-25 minutes.<br>An arterial blood gas sample will be taken from an arterial line and a standard blood gas analyser will be used to determine the PaCO2.[ Over the period from 5 minutes post induction to 25 minutes post induction]