An investigation of transcutaneous vagal nerve stimulation on return of bowel function and inflammatory markers after colorectal surgery

niversity of Leeds0 个研究点目标入组 40 人开始时间: 2017年10月18日最近更新: 2021年9月27日

适应症

试验速览

2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33539637/ (added 13/09/2021)

•1. Aged greater than 17 years
•2. Able to provide written informed consent
•3. Able to use the device and comply with study procedures
•4. Confirmed diagnosis of colorectal cancer via radiological or histological modalities
•5. Undergoing elective laparoscopic colorectal resection

•1. Acute infective or inflammatory condition
•2. Pre-operative, therapeutic radiotherapy
•3. Previous MI (STEMI/NSTEMI) or cerebrovascular disease (CVA/TIA) or known peripheral vascular disease
•4. Known congestive heart failure (NYHA>2),
•5. Known cardiac dysrhythmia (Previous VF, VT, AF, SVT, Heart block)
•6. Known history of seizures or recurrent syncope in the last five years
•7. Known chronic inflammatory condition of the gastrointestinal tract
•8. Previous neck surgery, or other abnormality distorting the cervical anatomy
•9. Previous vagotomy at any anatomical location
•10. Any in-dwelling device, stimulator or non MR compatible metallic implant
•11. Known or suspected intra-occular metallic bodies
•12. Regular medication known to mediate systemic inflammation (e.g. NSAIDS)
•13. Psychiatric, cognitive or behavioural problems which may affect study procedures
•14. Belonging to a vulnerable population (homeless, prisoner)
•15. Current pregnancy

发起方

niversity of Leeds