Effect of Intravenous Tranexamic Acid on Brain Hemorrhage
Not Applicable
- Conditions
- Head injury.traumatic intracerebral haemorrhage , Epidural haemorrhage Extradural haemorrhage (traumatic), Traumatic subdural haemorrhageS06.3 - S0
- Registration Number
- IRCT20200222046576N1
- Lead Sponsor
- Ahvaz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 94
Inclusion Criteria
The age above 18 years old
The existence of hemorrhage in brain CT scan including subdural hematoma, epidural hematoma, intracerebral hemorrhage and intraventricular hemorrhage
less than 8 hours passed from trauma
The absence of coagulopathy
Exclusion Criteria
patients with GCS of 3
macroscopic hematuria
history of anticoagulant medication
active vascular thrombosis or a history of it
hypercoagulative state
congenital or acquired hypercoagulopathy
history of vascular disease
valvular heart disease
renal failure
diabetes mellitus
pregnancy or breastfeeding periods
history of allergic reaction to TXA
history of seizure
history of brain stroke
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Brain hemorrhage volume. Timepoint: diameter and volume of traumatic intracerebral hemorrhage before intervention and 6, 24 , 48 hours after intervention. Method of measurement: Volume in ml of blood in the brain CT scan on the hospital's network. It calculate by multiplying the maximum length in maximum width in number of cuts of hemorrhage in centimeter divided by the 2,and registering on designed form.
- Secondary Outcome Measures
Name Time Method evel of consciousness. Timepoint: upon admission and discharge. Method of measurement: Glasgow coma scale.;Midline shift. Timepoint: before intervention and 6, 24 , 48 hours after intervention. Method of measurement: spiral brain CT scan.