Cognitive Changes After Surgery in the Elderly: Does Minimally Invasive Surgery Influence the Incidence of Postoperative Cognitive Changes Compared to Open Colon Surgery?
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Confusion
- Sponsor
- New York Hospital Queens
- Enrollment
- 52
- Locations
- 1
- Primary Endpoint
- Confusion
- Last Updated
- 13 years ago
Overview
Brief Summary
A study will be conducted to determine if there is any cognitive benefit in elderly patients having open versus minimally invasive colon cancer surgery.
Detailed Description
Cognitive changes in the elderly are common after surgery. It is not known if minimally invasive or laparoscopic surgery can prevent these changes. A study will be conducted on patients scheduled to have abdominal surgery. The patients will have cognitive evaluations before and after surgery. A small amount of blood, about 2 tablespoons, will be collected no more than 5 times in 6 months. The results will be analyzed to determine if there are changes between those having open surgery versus patients having laparoscopic or minimally invasive surgery, and if these changes coincide with cognitive changes.
Investigators
Mitchell Chorost
Principal Investigator
New York Hospital Queens
Eligibility Criteria
Inclusion Criteria
- •Patients over age 65.0 years and in need of elective colon resection for adenocarcinoma
Exclusion Criteria
- •Inability to complete preoperative cognitive screening
- •Inability to complete study in English since CANTAB is timed and not validated with interpreters
- •Emergency surgery
- •Depression or psychiatric comorbidity
- •Pre-existing dementia
- •Previous cerebrovascular accident or "stroke"
- •Previous myocardial infarction
- •Cardiac ejection fraction below 55%
- •Propranolol, metoprolol or other betablocker use
- •Digoxin, procainamide, or amiodarone use
Outcomes
Primary Outcomes
Confusion
Time Frame: 6 Months
Confusion assessed by questionaires and cognitive testing
Secondary Outcomes
- nutritional status(6 months)
- degree of inflammation(6 Months)
- pituitary-thyroid axis disruption(6 months)
- presence of electrolyte imbalance(6 months)
- liver function tests(6 months)