Prospective Observational Clinical Study on Changes in Cognitive Levels in Elderly Patients Before and After Hematopoietic Stem Cell Transplantation
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Hematopoietic Stem Cell Transplantation
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
- Enrollment
- 20
- Primary Endpoint
- To observe changes in cognitive levels in patients aged ≥55 years receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT) before and after allo-HSCT.
- Status
- Not Yet Recruiting
- Last Updated
- last year
Overview
Brief Summary
To investigate the potential improvement in cognitive levels in elderly individuals following hematopoietic stem cell transplantation, which will help better understand the changes in cognitive levels after transplantation in elderly patients, providing crucial reference for future clinical practice and research.
Detailed Description
To investigate the potential improvement in cognitive levels in elderly individuals following hematopoietic stem cell transplantation, which will help better understand the changes in cognitive levels after transplantation in elderly patients, providing crucial reference for future clinical practice and research. To observe changes in cognitive levels in patients aged ≥55 years receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT) before and after allo-HSCT.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age greater than or equal to 55 years;
- •Patients planning to undergo allogeneic hematopoietic stem cell transplantation.
Exclusion Criteria
- •Patients with active diseases;
- •Presence of central nervous system tumor invasion;
- •Planning to undergo two or more transplantations;
- •Severe cognitive impairments or mental illnesses;
- •Inability to communicate in Mandarin.
Outcomes
Primary Outcomes
To observe changes in cognitive levels in patients aged ≥55 years receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT) before and after allo-HSCT.
Time Frame: 1YEAR
1.Post-transplant Assessment: Cognitive level follow-up assessments at 1 month, 3 months, 6 months, and 1 year post-operation. Evaluation content is consistent with pre-transplant assessments. Cerebrospinal fluid testing is scheduled for 3 months post-transplant.4. Survival and Disease Follow-up: Follow-up for one year after transplantation to observe overall survival rate, disease-free survival rate, etc.