Comparison of preoperative administration of pregabalin and duloxetine for postoperative pain

The pain pattern after laparoscopic cholecystectomy is complex and distinct from postoperative pain after other laparoscopic procedures, suggesting that procedure specific optimal analgesic management plans should be proposed. Duloxetine is a SNRI  which is being used as an adjunct for management of neuropathic pain and attenuation of postoperative pain especially in lower limb surgeries. Pregabalin ,a structural analogue of GABA , reduces opioid consumption and postoperative pain after major surgeries. However, the comparison of these drugs on global postoperative quality of recovery in laparoscopic surgeries has yet to be evaluated. An interventional randomised study will be conducted in 260 adult patients of American Society of Anesthesiologists(ASA) grade I-III aged 18-65 years scheduled for laparoscopic cholecystectomy under general anesthesia who will be randomly and equally divided into two groups I,II. Group I 130 patients will be administered preoperatively 75 mg of capsulePregabalin orally and group II 130 patients 60 mg of capsule Duloxetine orally one hour prior to the surgery. Postoperative analgesic efficacy will be compared in both the two groups by using VAS score at 0 min, 1,2,4,8,12,24 hours along with assessment of sedation using Numeric Sedation Scale at 0,1,2,4,8,12 and 24 hours, time to first rescue analgesia and total amount of rescue analgesia required in first 24 hours.