Destiffening and Hypotensive Effects of Whole Milk and Full-fat Dairy Products
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Seated blood pressure
研究概览
简要总结
The specific aim of the proposed study is to address the efficacy of conventional full-fat dairy products as part of the normal routine diet for improving vascular function and reducing blood pressure in middle-aged and older adults with elevated blood pressure. The investigators hypothesize that dietary intervention including whole milk and full-fat milk products will induce significant decreases in systolic blood pressure and arterial stiffness. The investigators also test the hypothesis that the reductions in blood pressure will be associated with the corresponding decreases in arterial stiffness and/or increases in endothelial vasodilatory function as well as improvements in arterial baroreflex sensitivity. If our hypotheses are supported by the results, the information could be used as a basis for recommendations for the use of whole milk and full-fat milk products in the secondary prevention of elevated blood pressure and vascular dysfunction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Prehypertension or stage-1 hypertension
排除标准
- •Consume > 3 servings of dairy or fruit per day
- •Strenuous physical activity > 3 time per week
- •Lactose intolerance, pregnancy, lactation, and/or alcohol abuse
- •Taking cardiovascular-acting drugs
- •Overt cardiovascular disease, metabolic disease, GI disorders and/or renal disease
研究组 & 干预措施
Dairy
Add 4 daily servings of high fat dairy to diet for a period of 4 weeks
干预措施: High fat dairy (Dietary Supplement)
Plant-based
Add 4 daily servings of fruit to diet and/or plant-based milk, remove all dairy from diet for a period of 4 weeks
干预措施: Plant-based (Dietary Supplement)
结局指标
主要结局
Seated blood pressure
时间窗: 4 weeks
次要结局
- 24-hour ambulatory blood pressure(4 weeks)
- Flow mediated dilation(4 weeks)
- Carotid arterial compliance as measured by arterial pressure and corresponding cross-sectional area by ultrasound(4 weeks)
- Arterial stiffness as measured by pulse wave velocity between the aortic arch and femoral artery(4 weeks)
研究者
Stephen J. Roy
Principal Investigator
University of Texas at Austin