Comparison of Inflammatory Responses Subsequent to Different Cesarean Section Techniques

Not Applicable

Completed

• Conditions: Delivery; Inflammation; Cesarean Delivery
• Interventions: Procedure: cesarean section via the Pfannenstiel-Kerr technique; Procedure: cesarean section(C/S) via the modified Misgav-Ladach technique

• Registration Number: NCT02976311
• Lead Sponsor: Kayseri Education and Research Hospital

Brief Summary

In this study, the investigators aimed to find out whether there are any differences in inflammatory reactions occured subsequent to two different cesarean delivery techniques; modified Misgav-Ladach vs Pfannenstiel-Kerr techniques.

Detailed Description

Cesarean section is one of the most undertaken operations in women of childbearing age. However, there is not a unique cesarean surgery technique. Pfannenstiel , reported his own technique in 1897. Because of the applicability of the technique, it went down well among obstetricians. After three decades, Kerr evolved this technique, and Pfannenstiel-Kerr technique became the method of choice until late 70's. In 1972, Stark et al defined the Misgav Ladach technique and in the following years this technique became popular among obstetricians. In late 80's Misgav Ladach technique was modified and started to be more popular. But, still Pfannenstiel-Kerr technique continued to be used frequently and studies comparing clinical outcomes of these two techniques were conducted for several times. However, the inflammatory responses which occured subsequent to application of these techniques were not investigated. This is the first study investigating the inflammatory response emerged after different cesarean surgery techniques.

Study Timeline

• Study Start: 2016-04
• Primary Completion: 2016-08
• Study Completion: 2016-09
• Status Verified: 2016-11
• Study First Submitted: 2016-11-22
• Study First Submitted QC: 2016-11-24
• Last Update Submitted: 2016-11-24
• Study First Posted: 2016-11-29
• Last Update Posted: 2016-11-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 88

Inclusion Criteria

• Cesarean section for the first time
• Term,singleton pregnancy

Exclusion Criteria

• Any inflammatory disease
• Any pregnancy complication; IUGR,preeclampsia,preterm labor,preterm premature rupture of membranes
• Pregnancies <37weeks gestational age

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Pfannenstiel-Kerr	cesarean section via the Pfannenstiel-Kerr technique	cesarean section(C/S) via the 'Pfannenstiel-Kerr' technique
Misgav-Ladach	cesarean section(C/S) via the modified Misgav-Ladach technique	cesarean section(C/S) via the modified 'Misgav-Ladach' technique

Primary Outcome Measures

Name	Time	Method
TNF-alpha	24 hours	percentage of difference in serum IL-6 levels just before the beginning of the surgery and at the 24th hour of the surgery
IL-6	24 hours	percentage of difference in serum IL-6 levels just before the beginning of the surgery and at the 24th hour of the surgery