The Attenuating Effect of Soluble Fiber Consumption on Postprandial Glycemia in Humans
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Postprandial Hyperglycemia
- Sponsor
- Purdue University
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- Postprandial glycemic response
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The main objective of the current study is to investigate whether consumption of soluble fibers (isomaltodextrin [IMD], partially digestible maltodextrin) and RS4 starch will lower postprandial glycemia as well as postprandial insulin in human subjects with relatively high fasting blood glucose, when consumed with a specific amount of digestible carbohydrate (rice porridge). The primary outcome of the study is the effect of fibers on postprandial blood glucose, whereas the secondary outcome will be its effect on postprandial blood insulin.
Investigators
Bruce R. Hamaker
Distinguished Professor of Food Science
Purdue University
Eligibility Criteria
Inclusion Criteria
- •Body mass index (18.5 kg/m² ≤ BMI ≤ 29.9 kg/m²)
- •No history of abnormal glucose metabolism
- •No ongoing use of drugs affecting blood glucose levels
- •Fasting blood glucose between 90-110 mg/dL
- •Low dietary fiber intake (less than 15 g per day)
Exclusion Criteria
- •Diabetic individuals
- •Individuals with history of gastrointestinal disease
- •Pregnant or nursing women
Outcomes
Primary Outcomes
Postprandial glycemic response
Time Frame: Acute study: [3 hours of measurement after consumption of test food]
Blood glucose will be measured, (t max)
Secondary Outcomes
- Postprandial insulin response(Acute study: [3 hours of measurement after consumption of test food])