Effects Dietary Fiber From Grains or Fruits and Vegetables on the Intestinal Production of Short-chain Fatty Acids

University of Hohenheim1 site in 1 country21 target enrollmentJuly 6, 2020

ConditionsIntestinal Health

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Intestinal Health
Sponsor: University of Hohenheim
Enrollment: 21
Locations: 1
Primary Endpoint: Short-chain fatty acids (SCFAs)
Status: Completed
Last Updated: 5 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The aim of the study is to better understand the interplay between the intake of dietary fiber and intestinal bacteria, their metabolic activity and the effect on the intestinal barrier.

The effect of two different dietary fiber supplements is tested (arabinoxylan & ß-glucan versus inulin & fructooligosaccharides) in a randomized crossover intervention trial including healthy volunteers.

Registry

clinicaltrials.gov

Start Date

July 6, 2020

End Date

October 1, 2020

Last Updated

5 years ago

Study Type

Interventional

Study Design

Crossover

Sex

All

Investigators

Sponsor

University of Hohenheim

Responsible Party

Principal Investigator

Stephan C. Bischoff, MD, Professor

Prof. Dr.

University of Hohenheim

Eligibility Criteria

Inclusion Criteria

•18 to 65 years
•signed written informed consent
•willingness not to change the dietary pattern in the course of the study

Exclusion Criteria

•BMI below 18 or above 30
•acute or chronic gastrointestinal symptoms
•neoplastic diseases
•very strict diets, including raw foodists and frutarians
•regular smoking (more than one box per day)
•intake of antibiotics, immunosuppressants, or any intestinal therapeutics three months prior to study begin
•supplementation of fibers three months prior to study begin
•simultaneous participation in another clinical study
•pregnancy / breastfeeding
•relevant violations of the study protocol

Outcomes

Primary Outcomes

Short-chain fatty acids (SCFAs)

Time Frame: Will be measured in approx. 4 weeks after study completion.

SCFAs in native fecal samples

Secondary Outcomes

Gut microbiome composition(Will be measured in approx. 6-8 weeks after study completion.)
Gut barrier integrity(Will be measured in approx. 4 weeks after study completion.)