The analysis of mucosal immune responses induced by intranasal administration of an inactivated influenza virus vaccine in human (IV).
Not Applicable
- Conditions
- Influenza
- Registration Number
- JPRN-UMIN000009106
- Lead Sponsor
- ational Institute of Infectious Diseases
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
1. Volunteers with a fever at the time of planned vaccination. 2. Volunteers with serious acute diseases. 3. Volunteers considered inappropriate to be inoculated with the vaccine.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method eutralization, HI, and HA-specific antibody titers before and after intranasal vaccination. The proportion of memory B cells or plasma cells in peripheral blood mononuclear cells, and the cytokine profile.
- Secondary Outcome Measures
Name Time Method The analysis of the antibody repertoire induced by the intranasal vaccination. Survey on side reaction after vaccination.