nderstanding and manipulating neural compensatory mechanisms in SCA3 patients

Recruiting

• Conditions: Cerebellar ataxia; coordination difficulties; 10028037

• Registration Number: NL-OMON38791
• Lead Sponsor: Radboud Universiteit Nijmegen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Proven mutation of the SCA3 gene
Age > 18 years
Symtomatic ataxia
SARA score of gait is maximally 3 (they need to be ambulant)

Exclusion Criteria

Contraindications for MRI scanning (e.g. pacemaker, claustrofobic)
Epilepsy
Other neurological disorders
Other gait disorders

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Changes in grey matter volume (cerebellum or other brain areas)<br /><br>-Changes in functional connectivity between the cerebellum and the rest of the<br /><br>brain<br /><br>-Changes in the neural circuitry that supports gait and balance<br /><br><br /><br>We will focus on changes between patients and controls, as well as between<br /><br>patients before and after training</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>