The protective effect of tomato ketchup consumption on inflammation induced ex-vivo in human blood

Completed

• Conditions: Inflammatoire biomarkers, zoals cytokinen, chemotaxie en concentratie nutrienten (lycopeen, vitamine C en alpha-tocopherol) in humaan bloed; Inflammation

• Registration Number: NL-OMON35235
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 6

Inclusion Criteria

BMI 20- 30 kg/m2
Age >18 years
No reported physical and/or mental disease(s) or major surgery that might limit participation in or completion of the study
No reported renal and/or cardiovascular disorder(s)/disease(s)
No reported metabolic disorders/diseases in particular no diabetes mellitus type 1 and 2
No use of any medication that is known to influence lipid and glucose metabolism as well as blood pressure from at least one month before beginning of the study until the end of it

Exclusion Criteria

Use of any medication (1 month prior to the start of the study and during the study)
Consumption of 3 or more glasses of alcoholic drinks per day
Donation of more than 500 ml blood (<6 months prior to the start of the study)
Vegetarian lifestyle
Allergic to tomatoes or tomato products

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The study parameters are:<br /><br>a. The release of the cytokines TNF-a, IL-8 and IL-10 from blood upon ex-vivo<br /><br>stimulation with LPS.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secundairy parameters are:<br /><br>a. Chemotaxis of monocytes ex-vivo exposed to plasma.<br /><br>b. Plasma concentrations of lycopene and its stereoisomer, a-tocopherol and<br /><br>ascorbic acid.</p><br>