A relationship between cold hypersensitivity and genetic polymorphism: an exploratory observational study
- Conditions
- cold hypersensitivity
- Registration Number
- JPRN-UMIN000047040
- Lead Sponsor
- Keio University
- Brief Summary
Among the 1111 participants, 599 reported cold hypersensitivity. Higher cold hypersensitivity severity was positively associated with the SSS-8 scores. A GWAS for cold hypersensitivity was conducted using array-based genomic data obtained from genetic testing. We identified 11 lead variants showing suggestive associations (P??<??0.00001) with cold hypersensitivity, some of which showed a reasonable change in expression in specific tissues in the GTEx database.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Female
- Target Recruitment
- 1200
Not provided
1. Those who are currently diagnosed with heart failure, abnormal thyroid function (hyperthyroidism, hypothyroidism, chronic thyroiditis, or Hashimoto's disease), or malignancy (to potentially affect the evaluation) 2. Those who are currently hospitalized (as this may affect the evaluation) 3. Those who are currently pregnant or may become pregnant (as this may affect the evaluation). 4. Those who are judged to be excluded by the researcher (because it may affect the evaluation)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Association of genetic polymorphism with subjective symptoms of cold hypersensitivity
- Secondary Outcome Measures
Name Time Method Association of genetic polymorphism with site and burden of subjective symptoms of cold hypersensitivity Association of physical symptom burden to presence/absence, site, and burden of subjective symptomatic cold hypersensitivity