Cold urticaria and other cold-induced reactions – Comprehensive Evaluatio

Recruiting

Conditions: L50.2
Urticaria due to cold and heat

Registration Number: DRKS00017572

Lead Sponsor: Charité Campus Mitte Klinik für Dermatologie, Venerologie und Allergologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

All patients with a historical or physical evidence of CRs can be enrolled in the study.

Exclusion Criteria

Exclusion criteria are the following drugs that could affect cold stimulation testing results:
H1-antihistamines taken 3 or less days before enrollment (5½ plasma half-lives of drug elimination should be allowed) and/or glucocorticosteroids received 7 or less days before enrollment.
LST should not be done at skin sites affected by urticaria in the last 24 hours.

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
COLD-CE aims globally improve the understanding of cold urticaria and cold-induced anaphylaxis and to determine optimal evaluation strategies of patients experiencing CRs (cold-induced reactions).<br><br>The study will run for 1 year. Starting July 2020 all results will be analyzed and validated.

Secondary Outcome Measures

Name	Time	Method
A definition of percise criterias for an increased risk of systemic reactions (and consequently for prevention of anaphylaxis and an epinephrine autoinjector prescription).<br>Assessment of health-related quality of life (especially in patients with high temperature thresholds living in countries with cold climates).<br>Developement of new therapeutic recommendations.<br><br>The study will run for 1 year. Starting July 2020 all results will be analyzed and validated.