A relationship between cold hypersensitivity and genetic polymorphism: an exploratory observational study - A relationship between cold hypersensitivity and genetic polymorphism: an exploratory observational study

Among the 1111 participants, 599 reported cold hypersensitivity. Higher cold hypersensitivity severity was positively associated with the SSS-8 scores. A GWAS for cold hypersensitivity was conducted using array-based genomic data obtained from genetic testing. We identified 11 lead variants showing suggestive associations (P??<??0.00001) with cold hypersensitivity, some of which showed a reasonable change in expression in specific tissues in the GTEx database.