se of chlorhexidine mouthwash in preventing pneumonia in newborns who are put on the ventilator machine
Not Applicable
Completed
- Conditions
- Health Condition 1: null- To determine the effectiveness of prophylactic oral application of chlorhexidine in decreasing the incidence of ventilator associated pneumonia in mechanically ventilated neonates
- Registration Number
- CTRI/2011/08/001932
- Lead Sponsor
- PGIMER
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 104
Inclusion Criteria
All neonates intubated for mechanical ventilation
Exclusion Criteria
1.Suspected or proven lung malformations
2.Congenital lethal malformations
3.Refusal of consent
4.Investigator not available
5.Oral malformations (cleft palate and Pierre-Robin Syndrome) where application of chlorhexidine will be difficult.
6.Conditions whose radiological appearance will make VAP assessment difficult (CHD, HMD with white out lung, pleural effusion). CHD is defined clinically as presence of any of the given features : systolic murmur gr- III or more, diastolic murmur, cyanosis without apparent respiratory cause, antenatally diagnosed CHD, arrhythmia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Episode of VAP (ventilator associated pneumonia) per person-ventilation daysTimepoint: Episode of VAP (ventilator associated pneumonia) per person-ventilation days were recorded till 48 hours after extubation
- Secondary Outcome Measures
Name Time Method 1.Incidence of VAP <br/ ><br>2.Qualitative analysis of oral and tracheal micro flora <br/ ><br>3.Percentage of patients developing local or systemic adverse drug reactions to chlorhexidine <br/ ><br>Timepoint: Episode of VAP (ventilator associated pneumonia) per person-ventilation days were recorded till 48 hours after extubation and others were noted down while the patient received oral chlorhexidine application